ID A8UTM4_9AQUI Unreviewed; 852 AA.
AC A8UTM4;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 13-SEP-2023, entry version 82.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=HG1285_06475 {ECO:0000313|EMBL:EDP75950.1};
OS Hydrogenivirga sp. 128-5-R1-1.
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Hydrogenivirga.
OX NCBI_TaxID=392423 {ECO:0000313|EMBL:EDP75950.1, ECO:0000313|Proteomes:UP000005981};
RN [1] {ECO:0000313|EMBL:EDP75950.1, ECO:0000313|Proteomes:UP000005981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=128-5-R1-1 {ECO:0000313|EMBL:EDP75950.1,
RC ECO:0000313|Proteomes:UP000005981};
RA Reysenbach A.-L., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP75950.1}.
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DR EMBL; ABHJ01000003; EDP75950.1; -; Genomic_DNA.
DR RefSeq; WP_008286657.1; NZ_ABHJ01000003.1.
DR AlphaFoldDB; A8UTM4; -.
DR PATRIC; fig|392423.7.peg.3072; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000005981; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000005981}.
FT DOMAIN 681..697
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 423..454
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 486..520
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 852 AA; 97706 MW; 17E8EB1E92EABA53 CRC64;
MAEKNPELTP MLAQYHYFKN EYPECLLFFR LGDFYELFYD DAVVGSRELN LVLTSRPAGK
GRERIPMCGV PYHSADSYIR RLVQRGFKIA ICEQVEDPSK AKGIVRREVI RVITPGTHFE
KDSGGLACLH KRGKTYYVAY LNLSVGDFVG GKVQDTELLD FLSKFNIREL LVRKGEEVPA
EIVKTLNLFL TELEEEFYEE GSELVKESFK AYNARTLGFD EEEALLPLGA VYRYVKLTQK
GFTPFIKKPK PFQNEGFVRI DLKARRGLEL LESIEGRKDY SLFGVLDRTL TGMGRRRLRF
HILNPFRDVE RIREVQDAVE ELFRKEDKRR KLREILSDMA DLERLVSKVS SNMASPRDVL
HLKNTLFKVE ELREELRDMD SSLFRDIYGS LESLRELAEE IDRVLVEEPP VHLKDGGLIR
EGVDEYLDEL RFVRDNARKL LRDYERRLKE ETGISSLKVG YNKVMGYYVE VTKPNLKYVP
EYFRRRQTLS NAERFITDEL SRLEERILSA QSRINEIEYE LFVQLRDRIN TELERIGRNA
QLVGEVDYVQ SLAEVAHQRG WVRPEVNDSF DIRIEEGRHP VIDAFTRRYV PNDTLMNEDE
FLLVITGPNM AGKSSYIRQV ALLVLLSHMG SFIPAKKASI GNVDAIFTRI GSGDILAMGV
STFMNEMLDV AGMLSNATKK SLIVLDEIGR GTSTYDGIAI SKAIVEHISR ELGSRTLVAT
HFLELTELEG KVRGVKNYHM AVSEEESGVV FLYTLLEGKA EGSFGIEVAK MAGLPDSLIE
RAREILMSLE DKTLPVLEET FRKSEERIEE KEERSLMEEI LSLDIANMTP LQALVKLSEL
RDRIARVRGG TA
//
