ID A8UVI9_9AQUI Unreviewed; 583 AA.
AC A8UVI9;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=HG1285_00205 {ECO:0000313|EMBL:EDP75139.1};
OS Hydrogenivirga sp. 128-5-R1-1.
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Hydrogenivirga.
OX NCBI_TaxID=392423 {ECO:0000313|EMBL:EDP75139.1, ECO:0000313|Proteomes:UP000005981};
RN [1] {ECO:0000313|EMBL:EDP75139.1, ECO:0000313|Proteomes:UP000005981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=128-5-R1-1 {ECO:0000313|EMBL:EDP75139.1,
RC ECO:0000313|Proteomes:UP000005981};
RA Reysenbach A.-L., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP75139.1}.
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DR EMBL; ABHJ01000006; EDP75139.1; -; Genomic_DNA.
DR RefSeq; WP_008287209.1; NZ_ABHJ01000006.1.
DR AlphaFoldDB; A8UVI9; -.
DR PATRIC; fig|392423.7.peg.2286; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000005981; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048638; SelB-like_WHD3.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; SelB-wing_3; 1.
DR Pfam; PF21580; SelB_WHD3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EDP75139.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000313|EMBL:EDP75139.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005981}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 583 AA; 65936 MW; 8E75A6CC38228FA0 CRC64;
MKFVLFATAG HVDHGKTSLI RALTGIDTDR LPEEKRRGLT IDLGFAYLDF PEEGLRLELI
DVPGHERFIR NSVAGLSSVS GILLVVDAGE GVMPQTREHL SVAKLLGIKH GVAVLTKIDK
VEGEILELAE DELRNFLGEE DFELPVVKVS SLNGEGLELL RDRLREEALK ALENKEELPL
RVLVDSAFVV KGYGTVIRGS CVEGKVREGD RVVVEPLGVV SKIRKIQNHG KFVREAQAGE
RVALNLPDVN YDEVKRGFWV LKPGSYIKSG RMVVRSESLL KPGRLYSFFF GMREVRGRLS
HVGEGIFILR LEEGVVARRG DRAVVLDPTG RLAGGVEVIH PYPRVLKKSF IKENAGLLLE
SYEEYLLREM GPVGLSGELF RKLTGRAPNT GILERVSVKV GDRFYSKEFV EHLKKRLELF
IKERIGEEGY GVPKAELTER FGLSNTLFEY IISSLKNFRL LGEHVVDERN SDLTQNADFI
RLKELLREGI REEREILSAG VPKEVLSLSI KRRHVHRLGE FLIISEELLR HYEEKLRTLG
EGFTVQEAKK ATGLTRKFLI PLLEHLDFLG MTERKGDRRV WRR
//
