ID A8WPG2_CAEBR Unreviewed; 957 AA.
AC A8WPG2;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE Flags: Fragment;
GN Name=gcy-1 {ECO:0000313|WormBase:CBG00847};
GN Synonyms=Cbr-gcy-1 {ECO:0000313|EMBL:CAP22369.1};
GN ORFNames=CBG00847 {ECO:0000313|WormBase:CBG00847}, CBG_00847
GN {ECO:0000313|EMBL:CAP22369.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP22369.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP22369.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP22369.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
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DR EMBL; HE600951; CAP22369.1; -; Genomic_DNA.
DR RefSeq; XP_002629643.1; XM_002629597.1.
DR AlphaFoldDB; A8WPG2; -.
DR GeneID; 8573291; -.
DR KEGG; cbr:CBG_00847; -.
DR CTD; 8573291; -.
DR WormBase; CBG00847; CBP48157; WBGene00024177; Cbr-gcy-1.
DR eggNOG; KOG1023; Eukaryota.
DR HOGENOM; CLU_001072_1_3_1; -.
DR InParanoid; A8WPG2; -.
DR OMA; IVEYTEC; -.
DR OrthoDB; 2875278at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0001653; F:peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06352; PBP1_NPR_GC-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF265; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-1-RELATED; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 454..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 512..778
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 775..828
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 855..957
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAP22369.1"
FT NON_TER 957
FT /evidence="ECO:0000313|EMBL:CAP22369.1"
SQ SEQUENCE 957 AA; 108431 MW; 1B8D70A5D24F2365 CRC64;
AAAETNQTGS VGWSVCGGAV PLAIERLRQF GFVENFDFEY IVEYTECDLG SVVRAGMKFI
KEDKVDVIIG PPCAQALRTM SILASNSRKP VLGYGFVSDS DLSDVIRFPY LTTVLPNSQM
LGFAVAKVLQ QYHWSRVAML YYQSDIQYCS SVMTDVESTL SDPEADFDVN IVIKAEIYLN
DNQTTDIVLQ SVKSRARIIL WCSQTAFEKR DYLLKMSGHD MISDEYVHIM LSMRNIAFGV
QSSLGKSVFS QSGLTPIWES FSEGTDGFES IAKQAAQRML VLDVNSEVTD KAYLHYMQNN
IIRAVREAPM NCSTMACMSA NNTVMGAYAR HLFDVVYLYG VALTHTNSTD PEVYSNVDVI
VPQFITSFQG MTGEVKISTN LTRMSIFQLY GLNEHYDQVA YINFTFLNEK MNVSLFYKDE
GPTVWHFYSN HRPLDIPICG FLGKSCPVSF FQQYQLLIIV ALVVIILMLI TLIIGCCFIM
SSRRAEQLRI NSEWQIPFLS LMEPENRKNA HHTSKRSLQS AQTGESKTTA VSDFCENYTI
MIYEKDMVLT MKYQYMNLTK SDMEKFVKLR KLEHENLNKF IGLSIDGSQF ISVTKLCSRG
SLQDILSRGN FSMDYFFMFC IIKDVAEGLN YLHKSFLRLH GNLRSATCLV NDSWQVKLAE
FGIENLVENE IPPKKRLLWV APEVLRGSLT VSQMDPSADV YSFAIVASEI LTKKEAWDFL
DRKEDSEEIV YMVKKGGVFP IRPELITDIP DVNPDLTERL KAGQTVEPEG FDSVTVFFSD
VVKFTQLSQK CSPFQVVNLL NDLYSNFDTI IEEHGVYKVE SIGDGYLCSL QYSRQVAERL
KAGQTVEPEG FDSVTVFFSD VVKFTQLSQK CSPFQVVNLL NDLYSNFDTI IEEHGVYKVE
SIGDGYLCVS GLPTRNGYAH IKQIVDMSLQ FMEYCRKFKI PHLPREQVEL RIGVNSG
//
