ID A8WRC9_CAEBR Unreviewed; 728 AA.
AC A8WRC9;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=Hepatocyte growth factor-regulated tyrosine kinase substrate {ECO:0000256|ARBA:ARBA00015450};
GN Name=hgrs-1 {ECO:0000313|WormBase:CBG01567};
GN Synonyms=Cbr-hgrs-1 {ECO:0000313|EMBL:CAP23037.1};
GN ORFNames=CBG01567 {ECO:0000313|WormBase:CBG01567}, CBG_01567
GN {ECO:0000313|EMBL:CAP23037.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP23037.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP23037.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP23037.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
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DR EMBL; HE601298; CAP23037.1; -; Genomic_DNA.
DR RefSeq; XP_002634030.1; XM_002633984.1.
DR AlphaFoldDB; A8WRC9; -.
DR STRING; 6238.A8WRC9; -.
DR EnsemblMetazoa; CBG01567.1; CBG01567.1; WBGene00024786.
DR GeneID; 8576025; -.
DR KEGG; cbr:CBG_01567; -.
DR CTD; 8576025; -.
DR WormBase; CBG01567; CBP06103; WBGene00024786; Cbr-hgrs-1.
DR eggNOG; KOG1818; Eukaryota.
DR HOGENOM; CLU_013062_0_0_1; -.
DR InParanoid; A8WRC9; -.
DR OMA; DQQCSAK; -.
DR OrthoDB; 922060at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:EnsemblMetazoa.
DR GO; GO:0033565; C:ESCRT-0 complex; IEA:EnsemblMetazoa.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR GO; GO:0097499; P:protein localization to non-motile cilium; IEA:EnsemblMetazoa.
DR GO; GO:0031623; P:receptor internalization; IBA:GO_Central.
DR CDD; cd15720; FYVE_Hrs; 1.
DR CDD; cd21387; GAT_Hrs; 1.
DR CDD; cd03569; VHS_Hrs; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR017073; HGS/VPS27.
DR InterPro; IPR024641; HRS_helical.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46275; HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE; 1.
DR PANTHER; PTHR46275:SF1; HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF12210; Hrs_helical; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036956; Hrs_Vps27; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 12..140
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 157..217
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 300..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 477..549
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 577..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 82505 MW; E8E6A0C23B732D44 CRC64;
MASKFQKILE QATDSTLVEP NWEGIIACTD MIRSGEVPAK PSLQAIRKRL QHENPHVVNH
TLLVLDACVK NCGHKVHAEV ATREFMEDFK NLVTENKYDE VKNKSLEMLQ CWATAFANKP
EYKMVVDTHN LMKLAGFDFP SLKEADAMFM AQVAPEWADG PECYRCRSIF TVFTRKHHCR
ACGQIFCDKC SSREMALPQF GIEKEVRVCE TCYEKKVAEI KERYPALKKQ LAAAVAGKKS
VSTGGDSEAD RAAKEKLLRE KEEEDLALAI AMSQSEAEAK EKEKQNSLYH MYNGIKPETD
QGGYKGAAET STAPPADDAA ADPLARYLNR DYWQQKKEGK VEEWSGATST VGALSATAPP
PSEPSIAPSI CSTLMGPDEN SLNAEIAAMT LGATNGLNTS VSDDAKAQAD DTMRWCQSIK
DQVSVMDNRI RSNLARGRPV FNDSAIQDLF TRLTEFHSHV LSRMHTLDEQ RGYYEGLQDH
LANIGEARQA IDEMREEHER KRQERMAEEQ RLRQAQMQQT LEMMRIKKHA MLMEQREQAL
QRFQQQQQEM AMRRQQQAYY NPQMGYGAPP PGQHQPYYGY SQGQQAPAQY QPPQQTPQPQ
QYYQQFQNGP AAPPTSTNQH QPSMQQQYQQ QQQQYQGYYQ HQNYQQQGAY QQQHPQQLQN
YQNGGTSTPV ENGQYSQQGD VNQEHTSQMY QQPSVNGQNG YGNVDQNNVA AAHPPQQQMA
EQPLISFD
//
