ID   A8WT00_CAEBR            Unreviewed;       958 AA.
AC   A8WT00;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Protein CBR-ECT-2 {ECO:0000313|EMBL:CAP23611.2};
GN   Name=ect-2 {ECO:0000313|WormBase:CBG03012a};
GN   Synonyms=Cbr-ect-2 {ECO:0000313|EMBL:CAP23611.2};
GN   ORFNames=CBG03012 {ECO:0000313|WormBase:CBG03012a}, CBG_03012
GN   {ECO:0000313|EMBL:CAP23611.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP23611.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP23611.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP23611.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
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DR   EMBL; HE601438; CAP23611.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WT00; -.
DR   STRING; 6238.A8WT00; -.
DR   WormBase; CBG03012a; CBP47288; WBGene00025958; Cbr-ect-2.
DR   eggNOG; KOG3524; Eukaryota.
DR   HOGENOM; CLU_314547_0_0_1; -.
DR   InParanoid; A8WT00; -.
DR   OMA; ITANWRE; -.
DR   OrthoDB; 6929at2759; -.
DR   Proteomes; UP000008549; Unassembled WGS sequence.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 2.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR026817; Ect2.
DR   PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR   PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF52113; BRCT domain; 2.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT   DOMAIN          133..219
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          225..312
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          381..579
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          323..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          927..958
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   958 AA;  110117 MW;  CB2B31E33635A08F CRC64;
     MDVSMLSPQK RSRNIQKLAV WRGDVAQNKE MFDWLEEQKE VCIIKLHIYF RNRKLRFQKR
     KIEAVYYENL EELDSDWSEY TFFCGDFKSD LFRKLTQNQD TGTSAHLIVG TAVLKQKLKR
     RLDFMPLRPC RPLYCELMKN VTMKLSTEVT NKRELVELVH FMGGSVRKDT VQRTNVFIAA
     KVEAKVQSMT LVGVPTLRAD WITDCWENRD DPDYDVFRQD IVDKHKLGVF EGLSLYFHGF
     KKNEIDDMCF NLNNTGGTLA EDPSKATHVV YNPVNDDVET LPVSANQVHV TQEWFWVSLH
     RGWCALEDNF ALPTGTLRRK PLDNSTINSP LGKSLRSHNS RSLSSMRDCS GEGPSLNMTP
     DYIYSNDEVE NVGKSPRQPS KRLRVCMEMV DTERNYVSLL KLVIKFKEAL EKEIAQNEFM
     TKSDVAMMFG KLDPILELHE KIHAKLSSIM AEANSVLTAA NGKKNDDKSL DFAQVWIDAK
     DEMKKAYPQY INSFDTMKRF FDKQDRENSK FHTFCKAKES NPEFHRLKLT DLMVKPVQRL
     PSVALLLKEI GKKSESKLKH TAEEAQKVID EVLKVANKTR EKNDNLISHL SKFTDIENVP
     PTLVAANRMF CRELVVSPIA STSSRLSVVP RMKLFFFHDV LIVCFETGIQ LNFSKFLIQL
     TKIRSEKNTM QRLARHASFA SLHARQRRPY KYIDQIQLTT MRSAFRIRPP EEVSKFLEAH
     HTVHGIRPRE VFVWCLIHRD EQGGDTETVF ESSDCEEVRD FLDEIHLKLM SNCGRFFFQT
     EMADVNELND AHVADMTTRF FKNLCATKPQ TGHGSQMNIT EWSHNESMMG PPQSQSRMRR
     AFSNAQLTIT STLGFGRNQS RNNLARINEN SSFMASPRVS CDPAALANMT SVGMPGSVSE
     SESTPKRGLR ARLTSSTFLN RTHLVRNSSM RRQTHGFASQ SEIEPARSRT SSQRVTEL
//