ID A8X2Q3_CAEBR Unreviewed; 950 AA.
AC A8X2Q3;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Protein CBR-EGL-2 {ECO:0000313|EMBL:CAP26913.1};
GN Name=egl-2 {ECO:0000313|WormBase:CBG06635a};
GN Synonyms=Cbr-egl-2 {ECO:0000313|EMBL:CAP26913.1};
GN ORFNames=CBG06635 {ECO:0000313|WormBase:CBG06635a}, CBG_06635
GN {ECO:0000313|EMBL:CAP26913.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP26913.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP26913.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP26913.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE601320; CAP26913.1; -; Genomic_DNA.
DR RefSeq; XP_002647549.1; XM_002647503.1.
DR AlphaFoldDB; A8X2Q3; -.
DR STRING; 6238.A8X2Q3; -.
DR GeneID; 8589547; -.
DR KEGG; cbr:CBG_06635; -.
DR CTD; 8589547; -.
DR WormBase; CBG06635a; CBP39011; WBGene00028880; Cbr-egl-2.
DR eggNOG; KOG0501; Eukaryota.
DR HOGENOM; CLU_005746_3_3_1; -.
DR InParanoid; A8X2Q3; -.
DR OMA; HEMISNV; -.
DR OrthoDB; 66005at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF435; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01464; EAGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..90
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 93..145
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 566..667
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 770..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 107465 MW; B0888C2565C7B66A CRC64;
MPVGKRGLVA PQNTFLENVI RRCNNADTSF ILANAQVLDY PIVYCNDGFS KLVGYTRAEI
MQKPCSLAFM HGEHGEVGSL QKMQEALENA RTEQAEIGLC KKNKTPIWLL VHLAPIKNHK
DAVVLYLCQF KDITPLKQPL DDENNKGLSR ILQIARIAKS KQQFNQIETK DLHKSPGNTS
SNFNQVMNLG GDMLPQYRQE TPKTSPHIIL HYSSFKTIWD WSILALTFYT AFMVPFNIAF
KNSLRPFYLI STRDNPGGGI DSVALDSIVD VIFFADILLN FHTTFVGPGG EVVIEPSVIR
QNYFKSWFLI DLLSCLPYDI FYMFKRDDER IGSLFSALKV VRLLRLGRVA RKLDNYLEYG
AATLLLLLCA YVIVAHWLAC VWFWIGDTEV RLKMDNLTLP DGWLWKLSND LRQPYNVTAS
NKSTLIGGPS RTSAYISSLY YTMSCMSTVG FGNIASNTDN EKIFGVCMMI ISALLYAAIF
GHMTTIIQQM TSSTVRYHEM ISNVREFIKL QEIPKELAER VMDYVVSTWA MTKGIDTAKV
LGYCPKDMKA DICVHLNRKV FNEHSCFRLA SDGCLRSLAM FLELNHAAPG DLLYHTGESV
DALWFVVSGS LEVIQDDEVV AILGKGDVFG DEFWKANGST GQSAANVRAL TYSDLHMIKK
EKLMDVLDFY KAFANSFARN MTLTYNLTHR MKFRKVADVK REKELDAKRK NEKLTLPSDH
PIRKLLFRMR ERHGPRIFPS PMFADIEKGL KKSTEISRIS SLHSMVDETG GSSYIRSPRS
KQKRPPLLKR QTVDEDALSR TSWGLDKKDR EWSSLSNIKT EMKSKFDMIG ERLSIVEQIN
NRLAMLERAI IGNNGGANTP STMPVGSFSA LNESGNRLTL DAPPVARSVS WSEQHQSQWQ
RTVPPLRELE AGEWEPPFTP NPTTSSPQPT VPHIQIDEGE SARPPTRTRI
//
