ID A8X9N8_CAEBR Unreviewed; 1101 AA.
AC A8X9N8;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Protein CBR-EPAC-1 {ECO:0000313|EMBL:CAP29353.2};
GN Name=epac-1 {ECO:0000313|WormBase:CBG09801};
GN Synonyms=Cbr-epac-1 {ECO:0000313|EMBL:CAP29353.2};
GN ORFNames=CBG09801 {ECO:0000313|WormBase:CBG09801}, CBG_09801
GN {ECO:0000313|EMBL:CAP29353.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP29353.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP29353.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP29353.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
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DR EMBL; HE601459; CAP29353.2; -; Genomic_DNA.
DR AlphaFoldDB; A8X9N8; -.
DR STRING; 6238.A8X9N8; -.
DR WormBase; CBG09801; CBP16652; WBGene00031321; Cbr-epac-1.
DR eggNOG; KOG2378; Eukaryota.
DR HOGENOM; CLU_006829_1_0_1; -.
DR InParanoid; A8X9N8; -.
DR OMA; XVENLIN; -.
DR OrthoDB; 5473909at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT DOMAIN 22..115
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 285..351
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 410..510
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 551..689
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 830..1078
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 200..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1101 AA; 126838 MW; 49E0E3F52E0D3B86 CRC64;
MERMVSRVRR LSPLHTFSDA LLISLFSESD FQPDNIQQGV VLFEKDEPTE YWYLLLSGEV
QLYSKTYVSP SNFYLESSIF VQVGDFKHLK TLRCGSLFGD LSTLTHSCSC LVSRPAQLIK
IAQNHFLSVY NKHGDHLQPF IIIMHDILTD ETPMDPQLPM HSSGLFNGQR SNDLMSSEIN
PNEIVSVSTE GIPTKMILPS LPHRRENRSH RPNQLNHNQN HRTEDRNFIE FHNPTGIEKQ
VLESGEVLHR KMLTDNHQVI RDITTQHTVI FFRSSQSEYL NFQRVQNCMI GAEMIDWLLT
LFVSTSTTSS SLSRIQMSAI WQVLLNNGMI AHIDGEHEFM DKTNSYYRWV QPYRNRNKVA
PTIEEVSKST ALLSSIAPET LFLMIVSKPG FERSPEELEV VYEELTFIKA LSHLSTMVKR
QLANFVKVEQ YIHAGSVVFR QREIGVYWYI VLKGAVEVNV NGKVVCILRE GDDFGKLALV
NDLPRAATIV TYEDDSIFLV VDKHHFNQIL HQVEANTVRL KDYGEDVLVL EKVDIPRGAA
LENSNSCNFN CGYSVMAGKA EKILEYVLET RIDALSDDIS EIDLFVEDFI LTHDAFMPAN
TVCNFLKSYY FRTPYRATRD SITDSCTEEV RCKKRVVQFV YIWCSMLKIN FFLNPVTNSF
VEELFCHVID DRKRLGGMEE IMTRIGAIRT SRENMQLVLA RHPAIVLDCG VLSARTPCPI
LPSDVCNQII YLADTTCFVL PIRVDKTAEE ICELSRRRMS FSAEPLKLVE VKSNGEKLIF
SPTDRAIPTV LSLNSKLYVV NREEIPMLVP MEDQNGPTPT THSSILHLID SQELAHQLFL
FHLQLLRATD SNELLYQVIG RESFPQSMPF NLDLLVRRFN EVQHWSTTEI LLATEDNRVE
ILKKFIHIAT MLVKNETEWF ENIFYRAREY RDLLTVFAIT LGLSHTSVSR LTLTWNKLPP
ATFKTFSELE NLLDPTRNHR MYRLLVSKIA TPYIPFVPLI LKDLMFIHQG NKSFYNGLVN
FEKMHMFAKI FRNFRQCKSH MNDTTDHQYV EPQSLIRNLR VIDNQKILIQ LSYGIEPKTA
KRTVTKEIEN NGKRAIDSIC C
//
