ID A8Y1E0_CAEBR Unreviewed; 105 AA.
AC A8Y1E0;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Glutaredoxin-1 {ECO:0000256|ARBA:ARBA00013662};
GN Name=glrx-10 {ECO:0000313|WormBase:CBG22036};
GN Synonyms=Cbr-glrx-10 {ECO:0000313|EMBL:CAP38709.1};
GN ORFNames=CBG22036 {ECO:0000313|WormBase:CBG22036}, CBG_22036
GN {ECO:0000313|EMBL:CAP38709.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP38709.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP38709.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP38709.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Has a glutathione-disulfide oxidoreductase activity in the
CC presence of NADPH and glutathione reductase. Reduces low molecular
CC weight disulfides and proteins. {ECO:0000256|ARBA:ARBA00002549}.
CC -!- SIMILARITY: Belongs to the glutaredoxin family.
CC {ECO:0000256|ARBA:ARBA00007787}.
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DR EMBL; HE601428; CAP38709.1; -; Genomic_DNA.
DR RefSeq; XP_002638831.1; XM_002638785.1.
DR AlphaFoldDB; A8Y1E0; -.
DR STRING; 6238.A8Y1E0; -.
DR EnsemblMetazoa; CBG22036.1; CBG22036.1; WBGene00040679.
DR GeneID; 8580826; -.
DR KEGG; cbr:CBG_22036; -.
DR CTD; 8580826; -.
DR WormBase; CBG22036; CBP12076; WBGene00040679; Cbr-glrx-10.
DR eggNOG; KOG1752; Eukaryota.
DR HOGENOM; CLU_026126_7_2_1; -.
DR InParanoid; A8Y1E0; -.
DR OMA; YCHKARA; -.
DR OrthoDB; 203654at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0015038; F:glutathione disulfide oxidoreductase activity; IBA:GO_Central.
DR CDD; cd03419; GRX_GRXh_1_2_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR011767; GLR_AS.
DR InterPro; IPR047185; GLRX1.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR011899; Glutaredoxin_euk/vir.
DR InterPro; IPR014025; Glutaredoxin_subgr.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR NCBIfam; TIGR02180; GRX_euk; 1.
DR PANTHER; PTHR46185; GLUTAREDOXIN-1; 1.
DR PANTHER; PTHR46185:SF1; GLUTAREDOXIN-1; 1.
DR Pfam; PF00462; Glutaredoxin; 1.
DR PRINTS; PR00160; GLUTAREDOXIN.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW Redox-active center {ECO:0000256|ARBA:ARBA00023284};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 15..79
FT /note="Glutaredoxin"
FT /evidence="ECO:0000259|Pfam:PF00462"
SQ SEQUENCE 105 AA; 11361 MW; DF5D8C5202F721B9 CRC64;
MSKAFVDGLL QSHKVVVFSK SYCPYCHKAR AALDSVNVKP DALQWIEIDD RKDCDEIQNY
LGSLTGARSV PRVFINGKFF GGGDDTAAAA KNGKLAKLLQ EAGAI
//
