ID A9BEK5_PROM4 Unreviewed; 516 AA.
AC A9BEK5;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=prolycopene isomerase {ECO:0000256|ARBA:ARBA00012419};
DE EC=5.2.1.13 {ECO:0000256|ARBA:ARBA00012419};
GN Name=crtH {ECO:0000313|EMBL:ABX08515.1};
GN OrderedLocusNames=P9211_05841 {ECO:0000313|EMBL:ABX08515.1};
OS Prochlorococcus marinus (strain MIT 9211).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=93059 {ECO:0000313|EMBL:ABX08515.1, ECO:0000313|Proteomes:UP000000788};
RN [1] {ECO:0000313|EMBL:ABX08515.1, ECO:0000313|Proteomes:UP000000788}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9211 {ECO:0000313|Proteomes:UP000000788};
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene;
CC Xref=Rhea:RHEA:30971, ChEBI:CHEBI:15948, ChEBI:CHEBI:62466;
CC EC=5.2.1.13; Evidence={ECO:0000256|ARBA:ARBA00000004};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004900}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
CC {ECO:0000256|ARBA:ARBA00004258}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004258}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
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DR EMBL; CP000878; ABX08515.1; -; Genomic_DNA.
DR RefSeq; WP_012195137.1; NC_009976.1.
DR AlphaFoldDB; A9BEK5; -.
DR STRING; 93059.P9211_05841; -.
DR KEGG; pmj:P9211_05841; -.
DR eggNOG; COG1233; Bacteria.
DR HOGENOM; CLU_019722_4_1_3; -.
DR OrthoDB; 416321at2; -.
DR Proteomes; UP000000788; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046608; F:carotenoid isomerase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR014101; CrtISO.
DR InterPro; IPR045892; CrtISO-like.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR NCBIfam; TIGR02730; carot_isom; 1.
DR PANTHER; PTHR46313; -; 1.
DR PANTHER; PTHR46313:SF3; PROLYCOPENE ISOMERASE, CHLOROPLASTIC; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Isomerase {ECO:0000313|EMBL:ABX08515.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000000788}.
FT DOMAIN 19..500
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 516 AA; 57095 MW; 8EFBE9AE7AC78829 CRC64;
MTTYNQNNHW DVIVIGSGIG GLVTATQLAA KGVRVLVLES YTIPGGSSGA FSRNGYTFDV
GASMIFGFGK EGYTNLLTRA LADVSETCDT IPDPAQLAYH LPEGLNVVVD RDYEKFLTDL
TSLFPHEAKG IRRFYNVCWQ VFNCLDAMPL LSIEDPAYLT KVFFKAPLAC LGLARWLPFN
VGDVAKRYIK DKRLLNFIDI ECFCWSVMPA ERTPMINAGM VFSDRHAGGI NYPKGGVGII
AQKLVKGLEK NGGKILYKSR VTKILIENKK AVGVEIASGE KLFAKTIVSN ATRWDTFGGE
GVKEPLIDKV HEPSSEKRWR SRYKPSPSFL SLHLGVSKYS IPNNSHCHHL ILNEWNKMES
EQGVVFVSIP TLLDPSLAPD DHHIIHAFSP SSIDEWKRLT PSNYRKKKEE DSNHLISKLE
NIFPEISGKI SHKEVGTPRS HRRFLGRHNG SYGPIPSMRL PGLLPMPFNT TGIKGLYCVG
DSCFPGQGLN AVAFSGFACA HKIGARLGIN PWSLPD
//
