ID A9ENZ2_SORC5 Unreviewed; 750 AA.
AC A9ENZ2;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN OrderedLocusNames=sce0762 {ECO:0000313|EMBL:CAN90919.1};
OS Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS ce56)).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=448385 {ECO:0000313|EMBL:CAN90919.1, ECO:0000313|Proteomes:UP000002139};
RN [1] {ECO:0000313|EMBL:CAN90919.1, ECO:0000313|Proteomes:UP000002139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce56 {ECO:0000313|Proteomes:UP000002139};
RX PubMed=17965706; DOI=10.1038/nbt1354;
RA Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA Puehler A., Mueller R.;
RT "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL Nat. Biotechnol. 25:1281-1289(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
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DR EMBL; AM746676; CAN90919.1; -; Genomic_DNA.
DR AlphaFoldDB; A9ENZ2; -.
DR STRING; 448385.sce0762; -.
DR MEROPS; S09.076; -.
DR KEGG; scl:sce0762; -.
DR eggNOG; COG1505; Bacteria.
DR HOGENOM; CLU_011290_1_1_7; -.
DR OrthoDB; 9801421at2; -.
DR BioCyc; SCEL448385:SCE_RS03990-MONOMER; -.
DR Proteomes; UP000002139; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAN90919.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002139};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..750
FT /note="prolyl oligopeptidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002737483"
FT DOMAIN 59..461
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 531..737
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 24..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..53
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 750 AA; 80679 MW; 6B0A9A7CA01C1284 CRC64;
MNRLRTTPAL TLALPLLAAC SAPASRPLDK PAASPAAATP PPHAAPGAPS GPGRLPYPAT
AKRPVASEYH GTRVVDDYRW LEDGSSPEVE RWVAEQNQLS RAYLDAVPAR GAIRARVQEI
LSATSANHYA LDEAGGQIFA LKDQPPKQQP FLVVLRSVND PASARTLVDP EVIDPKGHTA
IDWFVPSRDG KKVAVSLSEG GTESGTVRVY DVATGKETGD TVPYANSGTA GGSLAWTGDG
KGFYYTRHPR PGERPREDMG FFQQIYFHKL GTPDKDDKYA LGTEFPRIAE VELTTSESGK
LVLASVQNGD GGEYWHYLLD ASGKWTRFAD LPDKVIRVVF GADDRLYLLS RKDAPRGKVL
RLSPGKLDLA RAELVVPESE AVIQDFLPTT GRLYVRDLLG GPSQVRVFDL KGKALGTVPI
PQVSSVRQVV RTQGDDMLFR GVSYTEPAAW FAYSARDGKV TKTPLAMTAP VSYADVEVAR
EACTSKDGTK VPINILRRKG APLDGTAPAL LTGYGGYGTS MAPGFNPLWR LWFDQGGVVA
IANLRGGGEF GEAWHRGGNL TKKQNVFDDF AACAQHLIDQ RVTSPARLAI RGGSNGGLLM
GALLTQHPEM VKAVVSHVGI YDMLRVELTP NGAFNVTEFG TVMDPEQFKA LYAYSPYHHV
KDGTAYPATL FLTGANDPRV DPWHSRKMAA RMQAASSGSA PILLRASGST GHGAGTPLSE
EIEEQADVFA FLFKELGLGA PPAKEDAAPR
//
