ID A9EWA0_SORC5 Unreviewed; 5844 AA.
AC A9EWA0;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:CAN94300.1};
GN Name=chiB {ECO:0000313|EMBL:CAN94300.1};
GN OrderedLocusNames=sce4137 {ECO:0000313|EMBL:CAN94300.1};
OS Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS ce56)).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=448385 {ECO:0000313|EMBL:CAN94300.1, ECO:0000313|Proteomes:UP000002139};
RN [1] {ECO:0000313|EMBL:CAN94300.1, ECO:0000313|Proteomes:UP000002139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce56 {ECO:0000313|Proteomes:UP000002139};
RX PubMed=17965706; DOI=10.1038/nbt1354;
RA Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA Puehler A., Mueller R.;
RT "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL Nat. Biotechnol. 25:1281-1289(2007).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM746676; CAN94300.1; -; Genomic_DNA.
DR STRING; 448385.sce4137; -.
DR KEGG; scl:sce4137; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_58_3_7; -.
DR Proteomes; UP000002139; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 2.
DR CDD; cd08953; KR_2_SDR_x; 3.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 1.10.1240.100; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR049490; C883_1060-like_KR_N.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF21394; Beta-ketacyl_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF08242; Methyltransf_12; 2.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002139};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 19..96
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 111..538
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1866..1943
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2003..2435
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3681..3758
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3840..4265
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5696..5773
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1317..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1951..1990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3647..3679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3774..3810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5604..5693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5794..5819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3775..3799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5844 AA; 622432 MW; 2F151C2CE6ABC3FE CRC64;
MMDGGSFDRE SDREDRSSDK KAALVGALRR AAAELLGRAK EDIDPGVPFR TLGLDSVGAI
ALLRRLSAEI DRALPLTLLW SYPTLESLAT HLARGPAKER AAAEGTPERQ DEPIAIIGMS
CRFPGADDID AFWSALCRGE SAIRSVPPDR WETAPGGGEE GAAPDRTSAS RWGGFLDRVD
GFDPLFFGIS PREAADMDPQ QRLTLELCWE AIEDAGVVPA TLKESRTGVY FGVLFGDYAA
LQSRRGIEAV TAYSSTGTSH CIVANRVSYF LELNGPSMTV ETACSSSLVA AHLACQAIRA
GECDLALIGG VNLMLAPDAA IGMHKLGVMS PTGRCWTFDA RADGYVRGEG GGVLLLKPLS
RAQRDGDRIY GVIRGSAVNN DGPSNGLTAP NPRAQEAVLR EACARAGVAP RSVQYVEAHG
TGTELGDPVE AAALGAVYGA GRPAEDGLRI GSVKTNIGHL EAAAGVAGLI KTVLCLHHRT
LVPSCNYETP NPHIDFGALR LGVVTGLAPW PESGEGPPRA GVSSFGYGGT NAHMVLEGLP
ERPTHLLPLA AARPDELAEE ARAWLRVLDG GARDVPLGEL CGAAASRVRA APCRLVAEGA
SRDALRADLS ARLASVASLK APPGAAPEGA ARPVFVFPGI GPQWAGMAQR LWMAEPVFQQ
ALARCDAALR EAAGWSLTEV LWADAARSPL ADPDALEAAF PALTAVQIAL VDLWRSFGVE
PAAVVGHSSG EVAAAYAAGI LSLDDAMRVA RELGAIYQRT VASGDGALAV VGANFEEVER
IAAEQGIGGA LHLAARNAPG SCLICGGRAA LQQLLGTLES RGVYCHGLNA MSSHCPLVEP
FAEAVDRLSA RLSPGRAVVP MISTVRAGPV EGGELGWHYW RDNICSPVRF DEAMRALALH
HRIYLELSPH PALLRYIPPH FDGAGEPPLV LESMRRDEDE HRTIRSAAAR LFEQGAALRW
EGLESAGDRR VLERELLDDG GERRQEPQPQ EPRLLPISAH TEEALADLVG RYRDHLARAA
WPALCASAAR RRAHHRRRLA VVAASGAEAD RKLGEVLRDG SRAIEGVARG RSSAEGPPRV
VFVLPSYEAA GAGASSAARV LSRWSPVFRE ALLACDRALA AHGCGVVAEL LAEGGASRLA
RPEVAHPAVF AVQIALVALL RSWGVVPEAV VGEGLGEIAA AHLSGALSLD EAARVVGGAA
LDASHSSTRN LREPSRLDEA IQGIALGRDA LFLEIGPEPA LAEVIQRSLQ RVEAQGVALP
LLQAGRDERE MMLRAAGELY CRGLDLDWSG LSPGGDHRVP LPRYAWQRQR YWLPDAPAPR
SAPGASTATA SGASATTTAP PAAAAPPAAA PPAAAAPPAA EASHAVRFYH AAWREAGGAA
GAPPEGPVLV LARDPSAGRA LARHLRGQPV VVVKPGEAFL QEDDTTFAIE PRRADHYRLL
AEKLRERGAA PRHVLHLWSL GAEAARESLA DKLDRGIHSL LPLLQEMRPR EGGAPLSVRY
VYPSSDRDPG HVHAAVAGFA RSVRQESDRL RLEVVGLSVA AHEAFHLDAW LGRIVGAWDG
GDEVEVRFEG SRRLVRRFAA LDPALSSEGS LALRAFKDEG VHVITGGAGG LGALFARHLA
RTSRARIALC GRSAPDPRTQ AVLQEIDALG GQAAYFQADI GDSGQAAALI QAVKRRFSRI
DGVIHAAGVL RDGLCLSKTR KDMAEVLAPK VLGTLALDEA TRDEPLDFFV MFSSFVGALG
NVGQSDYAYA NRFMDEFAVW REAQRARGAR TGKTLSIGWP LWREGGMQMD RSTAQRLELT
LGMSPLTTAT GLDAFDRGLR LPHETFLVLE GVPERLDRAL GVGTTVPAAR PRSAPRRSAT
AAEDAALNAR FQAELLEIIG AILSIAPRDI DPQEEMSAYG FDSTTFVELT NQLNTSYGVD
LTPSVFFEHR TIGSVVRTLC GSHGDAIRAR WSGPAARAGD GASGEPRNEG TAQGGPRVAG
GAPPAKAAPR RFQPAMAAGP LEREPIAVIG MSGVFPASDS VDELWSHLEA GRDVIEVIPR
DRWNWEEHWA SSEELDKTAV RWGGFMKHVD RFDAAFFGIS PREAALMDPQ QRILLEITWK
AIEHAGYRPS SLSGSRTGVY VGIGNADYRE VMARRLVPAE AHLATGALSH AIAPNRISYL
LNLHGPSEVV DSACSSSLVA VCRAVDALLA GECDTALAGG VNVIVSPTLY ISLSKAGMLS
PDGRCKTFDK DADGYVRSEG AGMLLLKRLS RALEDGDPIH GILRGHAVNH GGRVNTLTTP
NPSAQAALVA EAWRRAGVDP ATVSYIETHG TGTKLGDPIE IEALKKAFEA LFAQQGAAAP
DAPFCALGSI KTNIGHLETA AGIAGLIKIL LAMKHKKLPG NLHFRELNPY IRLEGSPFFV
LDRTVPWDPI EGAPRRAGIS SFGFGGVNAH VVVEDFEASE ARPGAAAVDA RAPRVVVLSA
RSEERLRAQA AQLCEHLRRV PFGAEPEVSR DLADLADLAD LVGRDLLLMA AGVLRHEPDD
IEPEGDLLEI GFDQVGLSVF TSRINERYHL HLTPHGLGAH HSLRTLAQHL CHSFEAPLRD
CYQAARAPSQ PSPAAGPIAL ADLAYTLQVG REPMNARLAV VASDIAELSD KLGLFVSGRD
RIEGLFHGSV RGRDDDLMHL VSGTEGRAFL DAILASQNLA KLARLWVLGA EVDWEMLYSP
GEAPRRISLP GYAFARDRHW FSPPEAPAAR ARDDRATILD DSSRGDARLD GISVTESERA
AGTARGDSML FVPRWVPRAL PAPAAGSPAP WAERTLVLYT QDGAPLKEAL VELLGRDRVV
ARRIEGGRGR TGEGPLELAM PGEAFGAVIF LGGVRARPWD VEDAQALEEG LEHGAFALLH
LVRELAARRA VDRPRRLCVV ASDVYPVLPG AHTNPAGATL YGLCRVLAHE LPELMVSCLD
LGLDEQGGAA ESSALLGLAR AVLDEPPHPD GAVTAIRRGQ RTCRVIAPAL LSEPAADAPT
LRPRGTYLIL GGAGRLGVDV SRFLARKLQA RLVWVGRSPL DAGIQAKIAA VEAEGGEVLY
AQADAADPAA LRAAVAHARA RFGAVNGAFH SALSYQGAPL ASMDTDTFAR VLSPKVQGSV
ALYRALADEP LDFLVFFSSI QSFTGDKSQS NYAAGCAFKD AFADHLRARA PFPVKTINWG
YWQSGDEEYD RRLVTLGYQA MPPEAGMEAL LRVLSSPVHQ ALAVKADDDV LAAMGVDLGH
EVILLPRRYP ALLSTTPAMG AAPAAEEVGR ALNALDELDR WGRRALARQL GAMGLFRAKG
RSIDREALRE HLGILPRHGR FFDAALSLLA REGVVRVEGD RVTVGAAPAF AVEAPGAPSG
PAFSGIGAHV ALLSTCLQHL PAILAGEALA TELLFSGGSM ARVEGIYRNN PVADHFNRLV
ARRVVEIVRA RLAHLGEGET LDLLEIGAGT GGTSAVVLEA LAPFASRIRY VYTDVSRAFL
RHGEQTFGQA HPFVAFERLD IERDPGEQGF LPGSFDVILA TNVLHATRSM RATITRVKRL
LRAHGWLIVN EQTAVQDYNT LTFGLLDGWW LSEDSELRVP GSPLLDAEGW RGLLAGLGFE
RIGLESTSIE GLRPTQHVIT AESDGWVLGE ARRPASGQLG ARAVVARERS EPAASERGTR
PVEATSAAPT GRPAGARSGE AVKERIAHRV AAEVALALGS TVAEVPTSAP FVEYGVDSII
GVDLVNRLNG AFGTALRATV LYDYPDVNAL SELLWQEHGE AIATRWTEVA RLDGEPPTRL
PEEQAPHRSA DDLFRHGPSR RDVPAPASAS ASAARSLAAP AMFTQADDGA AVGPAPRVVS
TDIAIIGMSG RFPGANGLDA YWQNLAAGVC SVTEVPRDRW DPAVFYDPDP RDVDKTYSKW
GGFLEDIDSF DASFFNISGK EADLSDPQQR LFLQEAFHAL EDAGYADASV SETRCGVFVG
ADRGEYLSLL RDEGARREGQ CVWGNDVSVL ASRISYFLDL KGPALAVHTA CSSSLVAVHL
ACRALMDGDC DMALAGGIFV NLTADWFILW SSGSMLSPAG ECRAFDNRAD GFVPGEGVGV
VVLKPLHAAL RDGDRILGII KGSGVNQDGR TNGISAPSTL SQTELEVSVY ERSGVSPATV
GYVEAHGTGT KLGDPIEVEA LTRAFRRFTD ERQYCAIGSV KTNIGHAATA AGMAGLLKIL
LAMQHGEIPP SLHFREANEH IDFASSPFFV STARTAWRPI GGAPRRAAIS AFGIGGTNAH
LVLEEPPARD RAPVRAAWPW YPVVLSARTE DALHRKIADL DRWLEQGGAD SDLGDVAYTL
AAGKPQFKHR AAFVASDGRG LLESTRAALR EGAAEGFVSP RSTAQPAAPQ ESGGRLVGEL
REARALPPQS VREKLLALAE LWVGGGAVDW KALLGEGSYQ RLSLPTYPFA QERHWFTARG
AGLSPRSGPL HPLLDALELS ESLGEGLSYV KDISGAAGVD LRLAGQTLLC PFALLEMARV
ALEHARPGSG SGLRAVSWGD LRPLHGGVHR LRVALHRQDG GLAFRIQADG KEGDLLSGQG
AVDAPGEGTG GEIAIASVIA RCPRRLDGEA FHASLEPRGL HEQAERRVIQ VVHVGDGEAL
ARYELPRSAA REPARIWLHP ALLTGALHVA ASLEEDRIEA SVPASLAGVE VSRAPRGSGF
LYARKIAEGR YHLAILDEEG QVCAKLQELR TRPLRRGARC ALFLPRWVAA PSRAGEGSRP
DAGGRDAGRT VVVVYPPAEQ ALASALTEVY GGERVLAVRL GSRTRRLDAR SWEVDTADPG
AWEQPLRDAS LVSTLHFLGG ISRDEASLHD GEALDRCLNQ GLFALFRLVK AVSRAGLMLA
PLRFQVVTSR AFPVLPGEVN ALYGGALLGW SRSLAGEYPG VRVEYVDLDL GEAGEPLTGA
AREAVLGALM DGSAEVAAWR GGQRFVPTIE PLSVPANERS AFRPGGVYLI VGGAGGIGHT
LGLHLARRYK ARLILIGRRP EDEEIRGKVR RIEALGGAAL YLRADVADPV ALRAAVDAGK
ARFGALHGVV HSALRLEDRT IDRMDEATLR AALAPKVQGS QVLCAVTRGE PLDFILFFSS
AQSQASRPGQ SNYAAASTFQ DAFALGLARR LDTAVKVLNW GYWGSVGVVA DDRHRERFAA
MGIGSIEPDE GMAAVEQALT ARVERVMPIK AEPHALVELG CDLGRQCQHY PESGLPVLQH
ARSSIGAPPA PAGVLLAFHD GFGELVRLGQ RCLLAAFQRL GVFRASGERY ELAALKAALR
IAPAHERLFP VLLAHLAEAG WLELDGGGSR ITVRSAPRVE RASLEHEKER LLARRPEIRH
HAELLWLCLE RYPDVLTGAV AATDVMFPGA SMEKVEGVHK GNVLTDYVNR RVVDVVLAYV
RERSPLLGGD ERIQVLEIGA GTGGTSEPVL EALAPYASKV RYVYTDVSRA FTRHGADAYG
PAYPFATFAL LDVERPVEQQ GFSPASFDLV LASNVLHATA ALRVALANAK ALLKAGGWLV
LNEVTENHPF NMLTFGLLKG WWLFDDATRR LPASPLLSAP MWEQLLREEG FTTPVSLGPP
GGMVLGFSQH VIVAQSDGVV SLPRQAAEGA EAEQTANARA PGRVEQAPGG AEPAAPHGRH
ANGNGNGAGP AAPPRHANGH GAEPAAPPRH ASGNGAAPPR WQGPPEAGKP EERAAQIGRD
VERAIVACLG EVLQTDRQRI DRDAPFTELG VDSLLSIRIV DRINKQLGIT LRTTDAYSYP
SVRELAGHVL SSFAADVRLP GAAKIDTAAL FGDGAAPAPA PAPAPVDEPR GGEPEGDEPL
WRLLRGVESG ALDVNEACRL LELP
//