ID A9FIU2_SORC5 Unreviewed; 1031 AA.
AC A9FIU2;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=protein-glutamate O-methyltransferase {ECO:0000256|ARBA:ARBA00012534};
DE EC=2.1.1.80 {ECO:0000256|ARBA:ARBA00012534};
GN OrderedLocusNames=sce1730 {ECO:0000313|EMBL:CAN91888.1};
OS Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS ce56)).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=448385 {ECO:0000313|EMBL:CAN91888.1, ECO:0000313|Proteomes:UP000002139};
RN [1] {ECO:0000313|EMBL:CAN91888.1, ECO:0000313|Proteomes:UP000002139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce56 {ECO:0000313|Proteomes:UP000002139};
RX PubMed=17965706; DOI=10.1038/nbt1354;
RA Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA Puehler A., Mueller R.;
RT "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL Nat. Biotechnol. 25:1281-1289(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-
CC glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:24452, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:10311,
CC ChEBI:CHEBI:29973, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:82795; EC=2.1.1.80;
CC Evidence={ECO:0000256|ARBA:ARBA00001541};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00050}.
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DR EMBL; AM746676; CAN91888.1; -; Genomic_DNA.
DR RefSeq; WP_012234365.1; NC_010162.1.
DR AlphaFoldDB; A9FIU2; -.
DR STRING; 448385.sce1730; -.
DR KEGG; scl:sce1730; -.
DR eggNOG; COG1352; Bacteria.
DR eggNOG; COG2201; Bacteria.
DR HOGENOM; CLU_000892_0_1_7; -.
DR OrthoDB; 9786165at2; -.
DR BioCyc; SCEL448385:SCE_RS08905-MONOMER; -.
DR Proteomes; UP000002139; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0008984; F:protein-glutamate methylesterase activity; IEA:InterPro.
DR GO; GO:0008983; F:protein-glutamate O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd16434; CheB-CheR_fusion; 1.
DR Gene3D; 1.10.155.10; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR Gene3D; 3.40.50.180; Methylesterase CheB, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR035909; CheB_C.
DR InterPro; IPR022642; CheR_C.
DR InterPro; IPR000780; CheR_MeTrfase.
DR InterPro; IPR022641; CheR_N.
DR InterPro; IPR036804; CheR_N_sf.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR000673; Sig_transdc_resp-reg_Me-estase.
DR PANTHER; PTHR24422; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR PANTHER; PTHR24422:SF25; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR Pfam; PF01339; CheB_methylest; 1.
DR Pfam; PF01739; CheR; 1.
DR Pfam; PF03705; CheR_N; 1.
DR Pfam; PF13596; PAS_10; 1.
DR Pfam; PF08448; PAS_4; 1.
DR PRINTS; PR00996; CHERMTFRASE.
DR SMART; SM00138; MeTrc; 1.
DR SUPFAM; SSF47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR SUPFAM; SSF52738; Methylesterase CheB, C-terminal domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50122; CHEB; 1.
DR PROSITE; PS50123; CHER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002139};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 59..234
FT /note="CheB-type methylesterase"
FT /evidence="ECO:0000259|PROSITE:PS50122"
FT DOMAIN 256..519
FT /note="CheR-type methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50123"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 706..771
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1017..1031
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1031 AA; 111610 MW; 734E6335FF5570D2 CRC64;
MPEQKKSRRT QLGAPGPSDA APQAGRASAP GRTPVPPEDA GESAAAGGPR AEGELRFPVV
CVVASAGGRG AIAELLRRLP SRDTSLSLVL IYSADPGELP LLELVAQSSP LPVAELRSGM
KLAPGRVQVL PPEAQATLAG LRVELAPRGE GSPGPGDLFL RSLAGELGSG AVAVVLSGAG
SDGALGLKDV KAEGGVTFAE NPRGAERPAL PRSAIAAGGV DFVLSVEEIA AELVRMGRPG
HVLAPWLRQG APLGMDADLS KLLRLLHAAV GVDFSQYKKS TLRRRIQRRM TLHRLATLQD
YLDHLRAHPG EIEDLYQDLL IKVTTFFRDP GAFAALKTHV FPVLMHSRPQ DSPVRIWVPG
CSTGEEVYSL AISLLEFLEA DATDHAIQIF GTDLSEAAIQ QARSGIYIES ISMDVSPSRL
RRFFVRVQGG FQVNKSVRDL CIFSRHNAAA DPPLLKLDLT SCRNLMIYLE PSLQRRLLQT
FHQALKPTGF LLLGSSESLT TAPDLFGVVD RTHRIFCKRA ASEAAHPLAL TAPALPGAPV
VALAPERPRE PEGFGMDAVR KEADAIVMAR YAPAGVVVDE EMQIVQFRGK TGPYLEPSPG
DASLHLFKMA REGLVLGIRA AIDASMNSGA MARKEQLKVR QDEKIRYVDV EVWPLKVRLP
QGRCFLVTFS ESGAARPDRP GSDPAPSDAQ KDLEIVQLRR ELVTTREYLQ SLIDELEATN
EELLCTNDEI LASNDELHRV NDALEGAHDE LESANQELTT VNEELRSSNV ALGLANDELR
KLLGGMNIPL LMVDADLRIR RIAGAADKLL GLAASDVGRS ILEVKSRSVA DIAPVVAEVL
GTMSTVERRV EDRDGRSYLM RARPSRTTDD EVDGAVICWL ESEAPRRAAR ELAGARDGLS
AVFEVLRHPF LLLDGELRIR AVTRRYCEQF MVPLGDIEGR SLSAIDAGWN TPQLEQQLRD
VLHRRAALVD FRLEAVLAHA GRRTLSFSAF RLQADEGELP ALLLVVEDRT APEIDPAGPP
GLRPARRAGP G
//
