ID A9JRI8_XENTR Unreviewed; 683 AA.
AC A9JRI8;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Anosmin 1 {ECO:0000313|Ensembl:ENSXETP00000055036};
DE SubName: Full=Anosmin-1 precursor {ECO:0000313|RefSeq:NP_001107160.1};
DE EC=3.4.21.4 {ECO:0000313|RefSeq:NP_001107160.1};
DE SubName: Full=Kal1 protein {ECO:0000313|EMBL:AAI55678.1};
DE SubName: Full=Kallmann syndrome 1 sequence {ECO:0000313|EMBL:AAI70858.1};
GN Name=anos1 {ECO:0000313|Ensembl:ENSXETP00000055036,
GN ECO:0000313|RefSeq:NP_001107160.1,
GN ECO:0000313|Xenbase:XB-GENE-488217};
GN Synonyms=admlx {ECO:0000313|RefSeq:NP_001107160.1}, hha
GN {ECO:0000313|RefSeq:NP_001107160.1}, kal
GN {ECO:0000313|RefSeq:NP_001107160.1}, kal1
GN {ECO:0000313|EMBL:AAI55678.1, ECO:0000313|RefSeq:NP_001107160.1},
GN kalig-1 {ECO:0000313|RefSeq:NP_001107160.1}, kms
GN {ECO:0000313|RefSeq:NP_001107160.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI55678.1};
RN [1] {ECO:0000313|RefSeq:NP_001107160.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI55678.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI55678.1}, and Gastrula
RC {ECO:0000313|EMBL:AAI70858.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000055036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000055036};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|RefSeq:NP_001107160.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29277616;
RA Bae C.J., Hong C.S., Saint-Jeannet J.P.;
RT "Anosmin-1 is essential for neural crest and cranial placodes formation in
RT Xenopus.";
RL Biochem. Biophys. Res. Commun. 495:2257-2263(2018).
RN [5] {ECO:0000313|Ensembl:ENSXETP00000055036}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_001107160.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC155677; AAI55678.1; -; mRNA.
DR EMBL; BC170858; AAI70858.1; -; mRNA.
DR RefSeq; NP_001107160.1; NM_001113688.1.
DR STRING; 8364.ENSXETP00000035317; -.
DR PaxDb; 8364-ENSXETP00000055036; -.
DR Ensembl; ENSXETT00000055036; ENSXETP00000055036; ENSXETG00000022299.
DR GeneID; 100135017; -.
DR KEGG; xtr:100135017; -.
DR AGR; Xenbase:XB-GENE-488217; -.
DR CTD; 3730; -.
DR Xenbase; XB-GENE-488217; anos1.
DR OMA; RPHLKHH; -.
DR OrthoDB; 2995832at2759; -.
DR Reactome; R-XTR-190373; FGFR1c ligand binding and activation.
DR Reactome; R-XTR-5654726; Negative regulation of FGFR1 signaling.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000022299; Expressed in heart and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00199; WAP; 1.
DR Gene3D; 4.10.75.10; Elafin-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR042447; Anosmin-1.
DR InterPro; IPR040957; Anosmin-1_Cys_box.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008197; WAP_dom.
DR PANTHER; PTHR14131; ANOSMIN; 1.
DR PANTHER; PTHR14131:SF5; ANOSMIN-1; 1.
DR Pfam; PF17869; Cys_box; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57256; Elafin-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS51390; WAP; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001107160.1}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..683
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001107160.1"
FT /id="PRO_5033207361"
FT DOMAIN 132..181
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 191..292
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 297..404
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 553..661
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 280..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 77224 MW; EE73BDFBCB9FB909 CRC64;
MWLREPGCRS LLTFILWITL VWGSRCAATA TAAAASSRKQ DESLSAQSIY RARCTSRCLS
LHITRISAYF KHFQNNGSLI WCQNHKQCSK CLEPCKETWD LRKNNCHNLC EPLFPKKHYE
CLTSCEFLKS VLSVKQGDCP APEKASGFAA ACVESCDADN ECSGVKKCCS NGCGHTCQVP
KNLYKGVPLK PRKELTFDEP QPGHLDIKWS SKFNISVEPV IYVVQRRWNY GIHPSEDDAS
NWQTMAQITD ERVQLSDIRP SRWYQFRVAA VNVHGTRGFT APSKHFRSSK DPSPPPAPTN
LRISNLTTNN EGTVSVRITW DLPEEPDIPV HHYKVFWSWT ANRKSVVPAK KKRRKTTEGS
QNSVALDGLQ ANSNYMVELQ AITYWGQVRL KSGKVSLYFS TSPPSTSLDQ ISKISKMKTD
ILAPPQRKRT ARMLEIGAPF YQDNQLQVKV YWKKTEDSML GLYHVQWFPE SCAHNETKGP
EKAVTQDHHI VLPALLFSCK YKVTVHPARP KDHLKAESIF FTTPPCSTLK GKTHKQINCP
SDTAPVVSKV LAKPENLSAT FNVQEANITG YFSWQLSKVN LHQPMTGFQV TWAEVTTESR
QNSLPNSIIS QSQILPADHY MLTVHNLRPS MLYKLEVQVL TTGGEGPATI KSFRTPDVLP
PLPHRPHLKQ HRPNHFKPSP EKY
//