ID A9JTS4_XENTR Unreviewed; 1233 AA.
AC A9JTS4;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Myosin-binding protein C, cardiac-type {ECO:0000256|ARBA:ARBA00044086};
DE AltName: Full=C-protein, cardiac muscle isoform {ECO:0000256|ARBA:ARBA00044215};
GN Name=mybpc3 {ECO:0000313|EMBL:AAI55457.1,
GN ECO:0000313|RefSeq:NP_001106379.1,
GN ECO:0000313|Xenbase:XB-GENE-479643};
GN Synonyms=cmh4 {ECO:0000313|RefSeq:NP_001106379.1}, fhc
GN {ECO:0000313|RefSeq:NP_001106379.1}, mybp-c
GN {ECO:0000313|RefSeq:NP_001106379.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI55457.1};
RN [1] {ECO:0000313|RefSeq:NP_001106379.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI55457.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=TGA IC {ECO:0000313|EMBL:AAI55457.1};
RC TISSUE=Tail {ECO:0000313|EMBL:AAI55457.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001106379.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. MyBP family.
CC {ECO:0000256|ARBA:ARBA00038352}.
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DR EMBL; BC155456; AAI55457.1; -; mRNA.
DR RefSeq; NP_001106379.1; NM_001112908.1.
DR GeneID; 100127177; -.
DR KEGG; xtr:100127177; -.
DR AGR; Xenbase:XB-GENE-479643; -.
DR CTD; 4607; -.
DR Xenbase; XB-GENE-479643; mybpc3.
DR OrthoDB; 4232090at2759; -.
DR Proteomes; UP000008143; Chromosome 4.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00096; Ig; 2.
DR CDD; cd05894; Ig_C5_MyBP-C; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR040849; MyBP-C_THB.
DR PANTHER; PTHR13817:SF20; MYOSIN-BINDING PROTEIN C, CARDIAC-TYPE; 1.
DR PANTHER; PTHR13817; TITIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 8.
DR Pfam; PF18362; THB; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 2: Evidence at transcript level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 350..425
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 439..533
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 632..724
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 733..829
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 831..926
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 930..1018
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1027..1122
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1140..1228
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1233 AA; 138478 MW; 2664D84E8C5E1A46 CRC64;
MPEPVKKSAF TKKPKSEEVS VGGTVTFAAE TDKPGLKVKW QRNNVDITAN ERFAIKSEGK
QHSLTISNAT AEDEVVYAVI AGTSKVKFEL KVKEQEKTEE APAPAPAAPE ASEAPAPPAP
DSSAPPPTET AEGEAKPPES AEATAIQPEP PKDEIGLFLE RPKDAEITVG SNIKFTARIA
GANLIKKPVV KWFKGKWMDL TSKVGKHLQL HEIYDRNTKI YTFEIQIIQA KTTYAGGYRC
EVSSKDKFDS CNFNLAVHEV STSGEVDIRA AFRRTGDGAE EAGELDFSAL LKKRDNEPKQ
GAEPDVDVWD ILKKAPPSEY EKIAFQYGIT DLRGLLKRLK KMKKEEKKSE AFLKKMDPAY
QIDKGQKMKL VVEVANPDAE VKWLKNGQEI RVSGSKYIFE SIGNKRILTI NNCSLADDAA
YQCVIGEEKC FTELFVREPP VQILHSLEDQ MVMVGERVEF ECEVSEEGAQ VKWEKDGVEL
TREETFKYRF KKDGKKHFLI INETTLEDGG NYKVKTNGGE SVAELMVQEK QLEVLQDVAD
LTVKAKEQAV FKCEVSDETV TGIWVKNGKE VIPNNRIKIT HIGRVHKLTI DDVVPQDEGD
YSFIPNGFAF SLSAKLHFME VKIDFVPRQE PPKIKLDCMS QCADTIIVVA GNKLRLDVPI
SGDPAPTVVW MKGDKLISEV DGRVHVETHA DHCVFIIEGA EKSDEGAYTV LVKNEAGEDK
ANINVKVIEV PDPPESPKIS NIGEDFCTVQ WDPPKYDGGQ PVLGYILERK KKKSYRWMRL
NYDLVKELTY ESKRMIEGVV YEMRIYAVNS IGMSLPSQPS QPFMPIAPTS EPTQLVVEDV
SDTSISLKWR PPERIGAGGL DGYTVEYCKE GSTEWVPALQ GLTERNSVMI RDLPTGERLT
FRVRAINLAG PSEPCTMKEP VTIREIMQRP KIWLPRYLRQ KLIKKVGETV NIVIPFQGKP
RPVVTWLKDG QPVDPKQVGI RNSEADTILF IRKAERDHSG EYKVQIQIEN CEDSATICIQ
IVDKPSASQK LKIVEIWGFN VALEWAPPQD DGNTEITGYT VQKADKKTME WFTVFEHYRR
THCVVSDLIM GNEYYFRVFS ENMCGLSEKP CTTKNSAYIQ KTGTAYKPPT YKDHEFDEAP
KFTHPLNDRS VVAGYNATLS CAVRGIPKPK ITWYKNKMDL SMEARYRSFS KQGVLTLEVR
KPSPFDGGLY TCKAVNEHGV AETECRLEVR VPQ
//
