ID A9KE17_COXBN Unreviewed; 690 AA.
AC A9KE17;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Intracellular signalling protein {ECO:0000313|EMBL:ABS78417.1};
GN OrderedLocusNames=CBUD_1171 {ECO:0000313|EMBL:ABS78417.1};
OS Coxiella burnetii (strain Dugway 5J108-111).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=434922 {ECO:0000313|EMBL:ABS78417.1, ECO:0000313|Proteomes:UP000008555};
RN [1] {ECO:0000313|EMBL:ABS78417.1, ECO:0000313|Proteomes:UP000008555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dugway 5J108-111 {ECO:0000313|EMBL:ABS78417.1,
RC ECO:0000313|Proteomes:UP000008555};
RX PubMed=19047403; DOI=10.1128/IAI.01141-08;
RA Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D.,
RA Williams K.P., Sobral B.W., Kupko J.J.III., Porcella S.F., Samuel J.E.,
RA Heinzen R.A.;
RT "Comparative genomics reveal extensive transposon-mediated genomic
RT plasticity and diversity among potential effector proteins within the genus
RT Coxiella.";
RL Infect. Immun. 77:642-656(2009).
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DR EMBL; CP000733; ABS78417.1; -; Genomic_DNA.
DR RefSeq; WP_011996947.1; NC_009727.1.
DR AlphaFoldDB; A9KE17; -.
DR KEGG; cbd:CBUD_1171; -.
DR HOGENOM; CLU_000445_105_5_6; -.
DR Proteomes; UP000008555; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 2.60.40.2380; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR011622; 7TMR_DISM_rcpt_extracell_dom2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF07696; 7TMR-DISMED2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..690
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002740165"
FT TRANSMEM 180..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..578
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 690 AA; 78674 MW; CED35A3C0BED898E CRC64;
MQYKLVRLIG LLWLLLSITH AYAGTLVLTD DAKDEYRSMA PYMEMYLDPT HQLTLQDFLK
YPEIYPFQKH DTNYIAKYIN IIIWFRFSVD NQTDHFQSYY LTSGRGVDPG WTIYEIKPNG
DIFKHPRGLG EYHYSLFYIS IPPHTKYQFY TSSYTVGVSL QNDFRLIRPR FELNVLNKSY
FVIGVCYASV ILLLPYSVIL FLILRKKEYL IYALYIFSFL LGLAVLDGTI NVIPYFVLST
PVCTYLAVLL AMLVAVFYGT FALVILKVKH FLPRIYRIIQ AYLFGVILAF SLTLIDVRLT
RQTVGVYILF IYLVFGVISL YLSFKKYTPA YYYLVGTLVL LVMTALGVLH ELHVISFDIF
FGQPTNFILS IEVVIHAFAL SAFFNYVTKS KEAMEQRAIK ANRTIIEEQQ KAIEAQEKLL
VSCSRFVPHE ALEFLNIKTV DAMKSGAHVD KPSTVLFADI VNFTAMANVS DVPKTFQYIN
TYTSSSSPVI RQHDGFVVKY FGDAILALFG GAQASVAAIQ SAIQMIHRLK KIKSTKQTDI
SIGVSITSGL AELGIAGSDD RMGIVLLGSP VNRATGFNSL TRLFRVAILI TEPVYQEIKL
SSQFHTRFLD QVSSIDKKKQ INVYEVFDAD EQTIIDKKVS IMPHYEAAIR DFNARKFKTA
LAQLKKCLSI LPDDQASQIY LERCQKELKQ
//
