ID A9LGN3_9STRA Unreviewed; 404 AA.
AC A9LGN3;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Tubulin alpha chain {ECO:0000256|RuleBase:RU000352};
DE Flags: Fragment;
OS Spumella-like flagellate JBNA45.
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Chrysophyceae; Chromulinales;
OC Chromulinaceae.
OX NCBI_TaxID=373001 {ECO:0000313|EMBL:ABX55866.1};
RN [1] {ECO:0000313|EMBL:ABX55866.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JBNA45 {ECO:0000313|EMBL:ABX55866.1};
RX PubMed=18319484; DOI=10.1099/ijs.0.65310-0;
RA Stoeck T., Jost S., Boenigk J.;
RT "Multigene phylogenies of clonal Spumella-like strains, a cryptic
RT heterotrophic nanoflagellate, isolated from different geographical
RT regions.";
RL Int. J. Syst. Evol. Microbiol. 58:716-724(2008).
CC -!- FUNCTION: Tubulin is the major constituent of microtubules, a cylinder
CC consisting of laterally associated linear protofilaments composed of
CC alpha- and beta-tubulin heterodimers. Microtubules grow by the addition
CC of GTP-tubulin dimers to the microtubule end, where a stabilizing cap
CC forms. Below the cap, tubulin dimers are in GDP-bound state, owing to
CC GTPase activity of alpha-tubulin. {ECO:0000256|RuleBase:RU000352}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000256|ARBA:ARBA00011747,
CC ECO:0000256|RuleBase:RU000352}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; EF577226; ABX55866.1; -; Genomic_DNA.
DR AlphaFoldDB; A9LGN3; -.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02186; alpha_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002452; Alpha_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF239; TUBULIN ALPHA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01162; ALPHATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352}.
FT DOMAIN 38..235
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 237..382
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABX55866.1"
FT NON_TER 404
FT /evidence="ECO:0000313|EMBL:ABX55866.1"
SQ SEQUENCE 404 AA; 44827 MW; 87CDA7D14DF48FD4 CRC64;
SRPQVGNACW ELFCLEHGIQ PDGRIPSDIS AQCDTDSFLS FFSETCAGKY VPRSIVFDSE
PTVCDEVRTG VFRLLYHPEQ IISGKEDAGS NFARGHYTLG KEHIDQVLDR IRRLADDCAS
LQGFMIYHAT GGGTGAGFGA LLMERLSVDY GKKSKLTLSV TPAPQVATAV VEPYNHVLAA
HSLLNHADVT FNLDIEALYD ICRRSLDIER PTYTNLNRLV AQVVSTLTSS LRYDGCLNAD
LAEFSTNLVP YPRVHFISTA YAPLVPWEKR GREVGMPVDV MRQAIDYSHH LVKIDPTHGK
YMSLCMMFRG DVVPRDIGPA IRDVKVRRSV RFVDWCPTGF KCGINYQPPP ALPGGDYAQV
SRAVCLLSNT TAIAEALAGL NHKFDVMYAK RAFVHWYVGE GMAR
//
