ID A9NIQ6_TRIVA Unreviewed; 462 AA.
AC A9NIQ6;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=MLH3 {ECO:0000313|EMBL:ABC61976.1, ECO:0000313|EMBL:AEW27283.1};
OS Trichomonas vaginalis.
OC Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC Trichomonas.
OX NCBI_TaxID=5722 {ECO:0000313|EMBL:ABC61976.1};
RN [1] {ECO:0000313|EMBL:ABC61976.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH-C1 {ECO:0000313|EMBL:ABC61976.1};
RA Pightling A.W.Jr., Stefaniak L.M., Malik S.-B., Logsdon J.M.Jr.;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABC61976.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH-C1 {ECO:0000313|EMBL:ABC61976.1};
RX PubMed=18663385; DOI=10.1371/journal.pone.0002879;
RA Malik S.B., Pightling A.W., Stefaniak L.M., Schurko A.M., Logsdon J.M.Jr.;
RT "An expanded inventory of conserved meiotic genes provides evidence for sex
RT in Trichomonas vaginalis.";
RL PLoS ONE 3:E2879-E2879(2008).
RN [3] {ECO:0000313|EMBL:AEW27283.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=T1 {ECO:0000313|EMBL:AEW27283.1};
RA Malik S.-B., Conrad M.D., Sullivan S.A., Jelcic M.J., Carlton J.M.;
RT "Trichomonas vaginalis, Pentatrichomonas hominis and Tritrichomonas foetus
RT meiosis-specific genes are less variable than housekeeping or mismatch
RT repair genes.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; DQ321766; ABC61976.1; -; Genomic_DNA.
DR EMBL; JF773735; AEW27283.1; -; Genomic_DNA.
DR AlphaFoldDB; A9NIQ6; -.
DR VEuPathDB; TrichDB:TVAG_352610; -.
DR VEuPathDB; TrichDB:TVAGG3_0133510; -.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
PE 3: Inferred from homology;
FT DOMAIN 282..418
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 462 AA; 53018 MW; DB55C9CEFCA7A7EF CRC64;
MSELIDHSAI ASELVMNSID ANAQNITVTL DLLLNQILVT DDGEGIQNLN AVFIKGGNTN
LNGVYKRNKS HLSRLISICD VDILSKTKDG KIQRKTFGDE HYIDNYYESG TTILLTKIFS
NNLIRIKEFT DPKNKLSLIN RFKRFICTIS LRFPHISFII FSSCQNQILN LPKVESLEKR
FIQITGVKPQ ILPDGKIMSF VDFSLNSFEN FLVNDFPCNR LFLGYEEVKI NEKCIQVKEG
SVIDYIWDRD GLTVMLSNEN QKVTKNFDTN EVGDVVIRNL EYVCVWDRKF ILATFQNKLY
SIDQHAAHER INLSKLMKRC FTERYPKTLK RPMMIHESFG ISFNEKSYEC LRKWGWRFNC
KEVTAVPCVC GVEIDDADGM IKYAIQCSTG NEPEIPDCIL DALRTRACKT AIKFGEFIDE
IRAKSLIYEL SISDRPNHCA HGRTVVAPIL DFDRPFSKFD GI
//
