ID A9QWL1_9SALA Unreviewed; 235 AA.
AC A9QWL1;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ABX76736.1};
OS Hemidactylium scutatum (four-toed salamander).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Salamandroidea; Plethodontidae; Hemidactyliinae;
OC Hemidactylium.
OX NCBI_TaxID=291265 {ECO:0000313|EMBL:ABX76736.1};
RN [1] {ECO:0000313|EMBL:ABX76736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18077422; DOI=10.1073/pnas.0705056104;
RA Vieites D.R., Min M.S., Wake D.B.;
RT "Rapid diversification and dispersal during periods of global warming by
RT plethodontid salamanders.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:19903-19907(2007).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU275898; ABX76736.1; -; Genomic_DNA.
DR AlphaFoldDB; A9QWL1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 124..231
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 132..199
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 177..228
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 187..230
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABX76736.1"
FT NON_TER 235
FT /evidence="ECO:0000313|EMBL:ABX76736.1"
SQ SEQUENCE 235 AA; 26498 MW; F4D2BA26E14CB9D7 CRC64;
ISYFSCMKAA PMKEVSLRAQ GSLPYPGLRT HGTLEGIGGP KTSSRGGLPS LADTFEQVIE
EILEDEQSMR PSEENKDADL FTPRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH
SDPARRGELS VCDSISEWVT ASDKKTAVDM SGQTVTVLEK VPVSKGQLKQ YFYETKCNPM
GYMKEGCRGI DKRYWNSQCR TTQSYVRALT VDNKKKVGWR FIRIDTSCVC TLTIK
//
