ID A9URG3_MONBE Unreviewed; 2199 AA.
AC A9URG3;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=[Histone H3]-dimethyl-L-lysine(36) demethylase {ECO:0008006|Google:ProtNLM};
GN ORFNames=MONBRDRAFT_23193 {ECO:0000313|EMBL:EDQ91917.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ91917.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ91917.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; CH991544; EDQ91917.1; -; Genomic_DNA.
DR RefSeq; XP_001743203.1; XM_001743151.1.
DR STRING; 81824.A9URG3; -.
DR EnsemblProtists; EDQ91917; EDQ91917; MONBRDRAFT_23193.
DR GeneID; 5888196; -.
DR KEGG; mbr:MONBRDRAFT_23193; -.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; A9URG3; -.
DR OMA; DNMYDVP; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR CDD; cd00173; SH2; 1.
DR CDD; cd00185; TNFRSF; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 6.
DR InterPro; IPR032179; Cry22Aa_Ig-like.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR15127; HEAVYWEIGHT, ISOFORM A; 1.
DR PANTHER; PTHR15127:SF32; HEAVYWEIGHT, ISOFORM A; 1.
DR Pfam; PF16403; Bact_surface_Ig-like; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF08007; JmjC_2; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM01411; Ephrin_rec_like; 6.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF57586; TNF receptor-like; 1.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1747..1769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 220..379
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 521..562
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 521..562
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 1022..1112
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 2100..2196
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 16..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1817..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..37
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..100
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 544..562
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 2199 AA; 235817 MW; 81C776F7B4352ADA CRC64;
MISKCDKVQH SGLCHFVIKR KATHKRKNQR KNKKKEQKKE QKKEQKKEQK KEQKNNKNKR
KNNKNKRKNN KNKRKNNKNK RKNKRKNKRK NKRKNNTSKS RQAGKRLNAN TARAVPLDDA
VTTTLDASPN EANPIRMVDP MLQIDTVVVP TLPEYADWPL LHRQLDQTMD QLLETGVVSL
RDSTGEIVVL DSIDGAVEGT TVDSLLAAGY SLVIKPEHEP SLSSSMHAFT VSNVISQQIQ
AHLGVVMSEH FYISPPSQRA LSPHTDGGDV FVHQWAGSKL WTLCVPKAPD CQDCTFADLA
LRAELAKSAF QGCTAYTDEQ LAGMECRTLD LQENELLYVP RGVVHYARAN STGLSAHATY
QVVPPSATWI DMVVDECSLA ATTRACNELK NQLLQADLGF RWLNFRFKDV HVAPVLPNKL
NASEYTLPST RLASLITRPA SNDESVTRTR RSSDRGYSGR GCGSCNQRCD DSCDGSCDWV
VGSCDDSCDS SCACNSGLDT VNDVCSTCGK GTYHDMVRCL SCGAGTYQDS ASHLSTSCKP
KSRCPAGTYD ANGGSSSSNT NCLACPAGSY QDATNHLETS CKTKTNTCPV GHYASNGGST
TSDRICAVCP DGTWMNINGN SAQQCYQKSV PCSPGQEVSN KGDKTADNIC AACSSNSYQP
SQGLAVQCTR KTNTCKAGEY VTNPDSLTSD YSCGICAAAC AAGNYQASAG QTSCLPCPVD
SYSDTSAATS CKPCDLSHGA YQDQTGQTSC DGCGVGSRLD LTTSSCIPCA AGKYQGQPYS
TVCIDCAAGK YSLASASVCS ACPAGTYSEL AQASACTQCP AGKFSASENS ISCARCSAGT
YQAQAGQSDC QTCQAGYTVN PDFTQCTDVT PPELTLAPNA IVRFEALTNT FVYPTVTATD
TSGERIVVTH TNNVQPDEVG TYDVTYSGED SAKNKGVLVV QVIIFAARKP VIVLLGPVVM
TLEVHTRFND PMGYVIDEGE PNNLNNTLAS NTSALDIDTL GTYYVVYSMH TPDSQGLTAS
PVRRTVHVVD TTPPVISLTQ GVNVTVEAGS TWSEPGFSIR DNYDTMAIGD VTVEPVALNL
KVPNGTVLTV DYMATDRSGN AVSITRYVLV LDRLAPTITL LNATRLTAEA GDLYFEFDAV
AEDQLDDDVD LSITYPDGVT VGGELQPPSL PFDYSIVYTA RDDVGNTAHA TRTLTVVDTK
APSLEAITSE VHLEAGAAYA INASWYSVRD NYKATPTIST NVSALPRTHV MTPYRANVQI
TATDSQGNRN ATSLRVLLVD TTAPMLTLIT SNVTSGTDFK ISDLVTAYDS NDGVLDSVVD
MNTHGTNVLD LPSTPTCPVD RIRSAASNAY QQARAERIRS TNTQVVGDAP AGSTYTVDFI
VTDAAGNSDS LRGVVLTLRD DTAPVIATSG TPTDQIEYTR AANQLELPLT ASDNLDGDIS
SWVCLSVARY APRTAERTPN VSRTGLLEPV SHNFNDFAEA GRPWGASGGR PLLLLDEPVG
TLYVVNASVM DGAGNTATRT FRYLIVDTTP PVLTLTYPGS YHVPYDTTFI DPGFTVFDES
DDLSEHVLVL NADRVNPRFP GTYVVQYRTN DRYGNPAEAA RSVIVDNFTL PADDAIVTIE
YAASISLAPF ARAFEEQLRG ALGYPYIFVV GRHAGADTTE DRFNTLPGSA SSSSSRRRSL
QAATNTSFEL CMRSTTTLAW VPAETLAGII RAWNNPNVTV TSIPLPPDPN NAASASTGNK
SGADAGLIGA IAGAAVGLVL VIVLVLVVLR RRNSSASKQL AAPSFQANSH SMANPLFDQD
VSGSVQASTY NHLALDGEYQ DVNPDDPGYD DFEDRPGFGS GPDEDDIDGD GGYFYTDVEG
AAPDAGTERA HATFVNEAYM SVDDDFNDSN EYHEAVPRAT MPDDTYGVEG DYALAVPSGG
ATETTYGLKL GNGAYGADNA YDQPTFMAST SAEYDVPMSA DDSQALAKGY AVPSVRDGPA
STSHYDVPLS SITEPAQYAA TELETLPVGS YILRYSDNTK QLVLSVRSRS RVQHHVLSIN
AQDEVLFNEK VMPGARDLAS AMHILSSPEL YQDFLSVPLW TADAADTAEG PAAGLDGEPY
FHGQIDRSEA EKRLLANGSD NAFLVRARSA GSYALSILSL KSKDAKCHHH LLEVNEEGLV
TLNNDLLSPP CTSIVGAVEL LRRVPPENID QPQVPVART
//
