ID A9V290_MONBE Unreviewed; 571 AA.
AC A9V290;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=MONBRDRAFT_26397 {ECO:0000313|EMBL:EDQ88216.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ88216.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ88216.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
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DR EMBL; CH991555; EDQ88216.1; -; Genomic_DNA.
DR RefSeq; XP_001746809.1; XM_001746757.1.
DR AlphaFoldDB; A9V290; -.
DR EnsemblProtists; EDQ88216; EDQ88216; MONBRDRAFT_26397.
DR GeneID; 5892200; -.
DR KEGG; mbr:MONBRDRAFT_26397; -.
DR eggNOG; KOG1378; Eukaryota.
DR InParanoid; A9V290; -.
DR OMA; YASWSIP; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR PANTHER; PTHR45867:SF3; ACID PHOSPHATASE TYPE 7; 1.
DR PANTHER; PTHR45867; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF14008; Metallophos_C; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU361203};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361203}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT CHAIN 23..571
FT /note="Purple acid phosphatase"
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT /id="PRO_5005122274"
FT DOMAIN 158..251
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 266..467
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 488..549
FT /note="Iron/zinc purple acid phosphatase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
SQ SEQUENCE 571 AA; 63609 MW; C1D56088CA96D08C CRC64;
MVCLRAVLAL VGLAAFLSVG QAASLNACQL MPTCALAAAL PGCGWCWQST LTRDQQHGAR
LQQEKECSSH KCVFGLSAGN TAGPTDGSPC SDWTYEYIEC MQHVDCNALP DCQNILGTYC
GWCEDTKTGM RGNASGPEHG QCSNWISSID QCANITGPQH VHLSYAQQDT SMMVTFACRT
NTTALATYAS ANDAGSESRQ VPAVAHAFNG TGNPDGLQYI YRAELVGLER GAYYKYSVAC
EEQNSSTFTF QAKPRDPSPG NDWEAKFLVW GDMGRHGGSQ ALDRLTLEAS DDHRNVTTLI
HFGDFAYDLD DNGGINGDTF MTRIQQLASH KPYMTCVGNH EIEDGSFSNY LNRFTMPRYD
VNNGWDMLWH SWDVHLVHFI SYSTEVYFSN KFDIQRQYDW LEADLQAANA NRTLRPWIIA
FGHRPMYCSN LDGDDCTKNS SVVRAGLEDL FHKYGVDIVF EAHEHSYERL WPTYNNTVTQ
FDYINPKAAV HLVSGAAGCN EANGACLNPI LTGRLPWSAF RSSAQGTYSF GHLNIHNSTH
AYFDSYVVEE ERVEDFIWII QEHHGLRNMT L
//
