ID A9V325_MONBE Unreviewed; 1749 AA.
AC A9V325;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDQ87988.1};
GN ORFNames=MONBRDRAFT_26683 {ECO:0000313|EMBL:EDQ87988.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ87988.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ87988.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
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DR EMBL; CH991556; EDQ87988.1; -; Genomic_DNA.
DR RefSeq; XP_001747064.1; XM_001747012.1.
DR STRING; 81824.A9V325; -.
DR EnsemblProtists; EDQ87988; EDQ87988; MONBRDRAFT_26683.
DR GeneID; 5892487; -.
DR KEGG; mbr:MONBRDRAFT_26683; -.
DR eggNOG; KOG3542; Eukaryota.
DR InParanoid; A9V325; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT DOMAIN 58..104
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 421..490
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1048..1275
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 303..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1353..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1522..1686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1522..1537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1547..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1749 AA; 190945 MW; A24A80E022C6111F CRC64;
MTDIQVREPG EANGTTLPLG QRGRLDLAAV QAALNIPLDS RSDEDTNLIY TLLQAVPLLH
ALPAGAVRRL SQVAEAVQYH KGDTIFRAGE SVQAVYVVVQ GRVNCGKASR TAGDWLAEGF
SPAPATQHRG TAVVVGEPCT LARIPIEQYE HARLPRSPST QASRHIATEE LVLTPRVIGD
PASIALPALR VLRLGINPAT GADISTESNA LPPLPPAPLV SSLALQSKLV QFDHSLDAFV
SSPIAAEHKL TFTPKSAVRI NTPMRQHNDR SLLLDASITS ELPVADDPDD EDSALRPQIL
FSTIDPEDAE SENQEVPASS LASSPSIDNK RAAAALRPIR GRSTETGSTS RTMSMLSLEG
SLPQQRFSSG TRSRNLASRL TLRASMFMPE DRVRSALEKP PEQRHDNDVR ALETELGRLT
VFAFMPEPSR RKLCQQLQLQ EFYSSGSTVA TPSTAQKFWW VVYTGSVVVV PSAEQQSSAG
IILEEGEAIG FGCPLPGEGD LVATSSSNTQ VLRVTAEEYE AAMREGDTVT QEMKTNGKVV
VITERRSVPG QPSAGPMRVI IKASRNKLLA FLFERAGKSL DSDPHFMRDF LLTYRAFLTP
AELLKATKKA LSQVNTRPRA TEALEVHPPR FVRLNTRGIL EPKDALLQLG LTCSTQLYAA
AILLACHSEH VFFPQQPKGS PPPYTLVVSR VAPGSVAEDA GLQAGDMLLP SLQQQRDLDE
ATLLEHGVAL SDTGDVVLLT MDDVLKGALE HHSLTLVAMN DPTLAMHLRH ADYESGLMAA
YTRLASRKRS LSVSLSGSTA ASATGGNAHQ ATSVGPNPAT GISDMSPVKR RHSMATMDAP
SRGRKNSMLL PSPVGIFKRK RKESTPEEQV PDLIAQLCGL QEHFDHELCS VLKIYSQDWS
KHHYLAVNQI TRAEQVVLFL ARLWHFEIAP DRELRLLVLQ LDERGVAREY LVEQTGFVVR
CLEGSVRFLL VDVPADMSSP SRMERASSHS SIASAESRHT DGDQVSVSSH EPKHAAVVCR
YVNLNLITEN VRREMLDEVT HNIMNVNDID LLARVICEKQ WRMLRRVQPT EYVGLLWHKL
QLETANLDEL TEQFNWLVRL FKTAILRHKT DIKRRVDHLK RSIILARTMV KLGNLNGAFA
IVSALASSEV SRLKKTWSAL KSTVRQDFEN LESLIDPTRN MATYRTLYAQ LSKQRKAIPF
LPLVLKDLAF THEGNQTTVD GLINFDKLRM ISRQIHNLTD MCHDSEAVPA NLTWRQSGLT
LKQFHHRQEM ARSILEALAS QDVIENEEHF LGLSFFCEQS RHLLRHLKIS DPVPQYLGKA
ASRPLLDQAQ AMQKFGPTHL QLVSEEAVAT VHDAGAEQTA TAPESQKPEL SSEPVARVIL
RRADSSVARH SNEVAGQVGH YHNLKAIEEP VDVPANSAAA KQLRFIQAHS ISSLDGGLTY
EESGSAEPEA ATQATSALSK VTAIHGDDVS SRSVAAAIEN PPSGDCTDRD LDMASDNVHA
AAPAEVKVAA SRNDDMTAEA VANTEAEHDH DPSPLPRDKC SFENLSAKDG ASGSSTPTSV
PSSPRRHSYR QRTSSSGSLE GLSERPLFRR QSGIFDPEAL SARTPSKAPS NSPRPTDLPT
GKAPIPPTRD YDSDESDSSA GPAAPHMDEE DAERAVSVFS PEVGVVTSDP PAQATELNSD
QMEQEISDGV EDDFEQWLQG MMVSAPNADE DAVNDSTVTT STRAELDTTE LETLMASILA
PPPEGKALL
//
