ID   A9V819_MONBE            Unreviewed;       515 AA.
AC   A9V819;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Acid phosphatase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MONBRDRAFT_33870 {ECO:0000313|EMBL:EDQ86262.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ86262.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ86262.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC         Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000032};
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC       {ECO:0000256|ARBA:ARBA00005375}.
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DR   EMBL; CH991567; EDQ86262.1; -; Genomic_DNA.
DR   RefSeq; XP_001748932.1; XM_001748880.1.
DR   AlphaFoldDB; A9V819; -.
DR   STRING; 81824.A9V819; -.
DR   EnsemblProtists; EDQ86262; EDQ86262; MONBRDRAFT_33870.
DR   GeneID; 5894231; -.
DR   KEGG; mbr:MONBRDRAFT_33870; -.
DR   eggNOG; KOG3720; Eukaryota.
DR   InParanoid; A9V819; -.
DR   OMA; PAWPIRD; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR   CDD; cd07061; HP_HAP_like; 1.
DR   Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR   InterPro; IPR033379; Acid_Pase_AS.
DR   InterPro; IPR000560; His_Pase_clade-2.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   PANTHER; PTHR11567:SF110; ACID PHOSPHATASE 1, ISOFORM B; 1.
DR   PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR   Pfam; PF00328; His_Phos_2; 1.
DR   SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR   PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..515
FT                   /note="Acid phosphatase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002745375"
FT   TRANSMEM        430..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          393..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  57072 MW;  AA7ACB5C9017E0D9 CRC64;
     MSSLRRLAGL GLLLTALPLV LGELKLVQIL FRHGDRTALR DLPGVSQPSD WPEGYGQLTA
     LGMQMHYNVG AYFRKRYIQD LSFIDAAYNH EQIVVRSTDA DRTLMSAQAQ LAGWFPVETS
     VLGPPDILWR PVPVHTRPVE DDLLLRSWSQ GVCPRYDQLE ANWNQTQGWH DKNNQIVDPL
     ACQAVHLPAD QNCTVAQYLS ALEPISQIAP LDLDSLWQIS DTLLCRRMHN LSMPDYANHS
     DVGEASYSLL RSLEDWGMYA MFDSVPKRRL SGGPVLQELI SNMQAALQDS SMPRVFLYSG
     HDTNLAAVLE ALQTDHFRAR APPYASCLIV ELHVEDDTPF VRIVFKNESA IDAPEHPGHT
     LTVKTCEHSD CPLSEFVKVM SPILPTDMTV DCQAATPSPT TRASSSTTTK NVPASTIDPT
     SADAANKRDL TVTAVVVAIC LALAVAATFF ILFRRRQRRM RTIGTNIKYT SRSLAAPLSV
     VDDDDEEEDV FSSNYPNAPA QRPGRASRNQ SDAFA
//