ID A9VAE6_MONBE Unreviewed; 1288 AA.
AC A9VAE6;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDQ85471.1};
GN ORFNames=MONBRDRAFT_29199 {ECO:0000313|EMBL:EDQ85471.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ85471.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ85471.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
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DR EMBL; CH991573; EDQ85471.1; -; Genomic_DNA.
DR RefSeq; XP_001749662.1; XM_001749610.1.
DR STRING; 81824.A9VAE6; -.
DR EnsemblProtists; EDQ85471; EDQ85471; MONBRDRAFT_29199.
DR GeneID; 5894980; -.
DR KEGG; mbr:MONBRDRAFT_29199; -.
DR eggNOG; KOG0386; Eukaryota.
DR InParanoid; A9VAE6; -.
DR OMA; YGPGHKL; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IBA:GO_Central.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd04369; Bromodomain; 1.
DR CDD; cd17996; DEXHc_SMARCA2_SMARCA4; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029295; SnAC.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR10799:SF973; ATP-DEPENDENT HELICASE BRM; 1.
DR PANTHER; PTHR10799; SNF2/RAD54 HELICASE FAMILY; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14619; SnAC; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM01314; SnAC; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT DOMAIN 465..634
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 798..954
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1176..1246
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1261..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 316..343
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 112..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1288 AA; 146153 MW; 8522C86A31F7756A CRC64;
MSAALGGEPS VAGTQGAGVP TELQPLLSHD AADIYRVQVD TSNPLGKQTD QRRRSLTAAK
TYAALERVLE TIDVRDPAAV AELNESLQQT ELPENARRML FDMLRLRVVA SSGSDPASTP
TPVSSATPAQ LGRSDEGDET ARTYRQLARN LYPNNLAQED PEADQIVVAT PPKAFAASYK
AALRSAEFQL ASRVSFRVNE LQNLSSRVAL DHQVQALKEL HMLRLKDFQS AMRADLERFM
HHNTTPITAY RRGTLWRNRR VFMRDAALTA KEERFKQERE REAEKERHRS QLDILMDHRR
KFLAFHANVR TRLSALVADA DKAVKAKDRR AQLERERLEK ERLRLLMDQD TEGYLRLLDE
QKDSRKRILL DKIDERMRVV NKLIDAHQQQ ERARDEGQVS DAATLAAAAE SSNAGASEEV
KAGAEAALKA KFDAHVVQED IEEQPTILVG GKLKPYQMYG LRWLVSLYNN RINGILADEM
GLGKTIQTIA LLTYLVEKKN NSGPFLVIVP LATLSNWRLE LAKWAPSLVT VAYRGNKVER
RVFHQQIKDV RFNVLLTTYE MIIKDRALLS KACFNISWRY MIIDEGHRMK NSKNKLSQTL
MHYFSAPRRL LLTGTPLQNS LPELWSLLNF ILPDVFNSSD TFDSWFSAPF AETSENVELD
AEEKQLIILQ LHKILRPFLL RRLKKEVETQ LPDKVEHVIK CEMSALQRKL YVCMQKYGVI
PSSTQSTSGS NMEALDATKA RSLQNVVMQM RKLCCHPFLF KEVEQDLKSE LLRHEDAATA
LANLNGLELW RTAGKLELLD HMIPKLRRFG HRILLFSQFT TMLDILEDYF RYRRLKYCRM
DGTCGAAKRA ELLHDFNAPD SDLEIFILST RAGGLGLNLQ TADTVVIFDS DWNPHQDLQA
QDRAHRIGQT KEVRVFRLVT VQSVEERMLE RAREKLDVDQ QVIQAGKFNQ TADENDTKKM
LLEIIQQAND DDDEIEAGVT DHEDLNRMLA RSDEELEAFV QMDEEIANND QAWHSDRRQT
RLFARDELPA GLIDAENSVA KAIEEAAQEK PMEDYGRGAR VRKEVNYAED LTELQFLKAV
ESGSLDEARE RSAAKRKHRS RSGGAKADGK TTATSEGEQT ALELALGVLY ILLRIKLCVL
YTSERAQGRF ALISGDADVT AAENIINDLL SSTNRHGHVL SSSLMDLPSR AEEPGFYKRV
RKPISLRDIQ TKAMDQAYDS LDDLEADVDL LVDNVIDYYD DGEAIVDDAE QLRATFLSLR
QREEDDSELT PKAAKTSSRG RTPGSRRR
//
