ID A9VD43_MONBE Unreviewed; 619 AA.
AC A9VD43;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 13-SEP-2023, entry version 56.
DE RecName: Full=SH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MONBRDRAFT_30131 {ECO:0000313|EMBL:EDQ84576.1};
OS Monosiga brevicollis (Choanoflagellate).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ84576.1, ECO:0000313|Proteomes:UP000001357};
RN [1] {ECO:0000313|EMBL:EDQ84576.1, ECO:0000313|Proteomes:UP000001357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX PubMed=18273011; DOI=10.1038/nature06617;
RG JGI Sequencing;
RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT metazoans.";
RL Nature 451:783-788(2008).
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DR EMBL; CH991584; EDQ84576.1; -; Genomic_DNA.
DR RefSeq; XP_001750603.1; XM_001750551.1.
DR AlphaFoldDB; A9VD43; -.
DR EnsemblProtists; EDQ84576; EDQ84576; MONBRDRAFT_30131.
DR GeneID; 5895844; -.
DR KEGG; mbr:MONBRDRAFT_30131; -.
DR InParanoid; A9VD43; -.
DR Proteomes; UP000001357; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR046355; Gab1-4-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR PANTHER; PTHR45960:SF2; PROTEIN DAUGHTER OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..184
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 265..362
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 191..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 67323 MW; 3875F54C007566EF CRC64;
MGWLCAGPAV IRESPGRRQP GRFDSVYVYV YVCVCVVCVC VSLSPFWNFS LSLSLSLSLS
SLFSLSLVFF FSMSSDVVRN GWLIKSPPPG ALKGWKRRFF RFLRATNAGK ARMEYYVDPG
DVQRSMPKGI INLSDCTTVE EGPSEERRMK FFFRIVLPQR TYVLCAENRL ERDDWIKDLR
EELFAKAVAT PPAATPAPTP ALPSNPASPA HSSRNSASSG SQLPGHSVRQ PPPTPTPFQG
QPASSPSKDH GASRPQPKPV GPDNWLYGKI SRQMAEDLLA DYGHQQGMFI VRESSQRGSH
AVTVVHQGRV IHHLVTQTAG GLYLLNNQPC GSCASLEEVI DFLGTPHSTP VRWKSALIIS
PLDFDKNLLS GGANKRQSTA LPAYTSLPLQ SETEAPPSPS AATSVPASPA ACLAASLPRP
TNRPSHSEQV YSCQLCATDG ARRLGITANM RCDVRVIGRD FAVLNPANSV ELASWNVIGV
QSVCATPKQF EFVIVGSQPN PGHFCLETTE SQAILAALKP FLPPSAIRPS NSANVVEPGF
ELMSSALNDD DSDDERAVQD YQWDNHGVEE PPAPALPSRT VSAEPNNAAV PPLPRRDAKR
QYPGLPTRRR QEVGLQPRG
//
