ID A9XFY4_MUSDO Unreviewed; 781 AA.
AC A9XFY4;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Neuronal acetylcholine receptor subunit alpha-7-like precursor {ECO:0000313|RefSeq:NP_001295910.1};
DE SubName: Full=Nicotinic acetylcholine receptor alpha 5 subunit {ECO:0000313|EMBL:ABY40460.1};
GN Name=nAChRalpha5 {ECO:0000313|EMBL:ABY40460.1};
GN Synonyms=LOC101896226 {ECO:0000313|RefSeq:NP_001295910.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:ABY40460.1};
RN [1] {ECO:0000313|EMBL:ABY40460.1, ECO:0000313|RefSeq:NP_001295910.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Aabys {ECO:0000313|EMBL:ABY40460.1};
RX PubMed=18092998; DOI=10.1111/j.1365-2583.2007.00770.x;
RA Gao J.R., Deacutis J.M., Scott J.G.;
RT "The nicotinic acetylcholine receptor subunits Mdalpha5 and Mdbeta3 on
RT autosome 1 of Musca domestica are not involved in spinosad resistance.";
RL Insect Mol. Biol. 16:691-701(2007).
RN [2] {ECO:0000313|RefSeq:NP_001295910.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily.
CC {ECO:0000256|ARBA:ARBA00009237}.
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DR EMBL; EF203213; ABY40460.1; -; mRNA.
DR RefSeq; NP_001295910.1; NM_001308981.1.
DR ChEMBL; CHEMBL2366408; -.
DR DrugCentral; A9XFY4; -.
DR GeneID; 101896226; -.
DR KEGG; mde:101896226; -.
DR VEuPathDB; VectorBase:MDOA008152; -.
DR VEuPathDB; VectorBase:MDOA015403; -.
DR OrthoDB; 5489962at2759; -.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18997; LGIC_ECD_nAChR; 1.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF926; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA5, ISOFORM I; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ABY40460.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal {ECO:0000256|RuleBase:RU000687, ECO:0000313|RefSeq:NP_001295910.1};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 20..781
FT /evidence="ECO:0000256|RuleBase:RU000687,
FT ECO:0000313|RefSeq:NP_001295910.1"
FT /id="PRO_5038206421"
FT TRANSMEM 490..509
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 521..539
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 551..574
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 755..779
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 282..489
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 496..771
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 83..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 88485 MW; 1CA7E14CC60A1FB5 CRC64;
MMWEMLILWA VHLSLTAIAT LYANVRTALS QTAQQIVRAV IAATTLPIIQ RIQQQQHETE
KQQQQLQHGK HVEDIHLPAA GARYASASSS RLPPSSADAT IWPRAPPELP QTEKLSSAPP
PPSSSSTLLM QTKPAHKKPV HGRNFPPQQK NRMQPVSHLQ YQQQQQQQLS LPSPAEPQPQ
HYKQQQQQQG QERLGQQVNI NNITSSSNGG NTCSSNSFTA TTSIAATTTT SILTLWQHCH
RRYRPHQLLP LLTTKGLNKY SWIFLLIYLN LSAKVCLAGY NEKRLLHDLL DTYNTLERPV
LNESDPLQLS FGLTLMQIID VDEKNQLLVT NVWLKLEWND MNLRWNTSDY GGIKDLRIPP
HRIWKPDVLM YNSADEGFDG TYQTNVVVRN NGSCLYVPPG IFKSTCKIDI TWFPFDDQRC
EMKFGSWTYD GFQLDLQLQD ETGGDISSYV LNGEWELLGV PGKRNEIYYN CCPEPYIDIT
FAIIIRRRTL YYFFNLIIPC VLIASMALLG FTLPPDSGEK LSLGVTILLS LTVFLNMVAE
TMPATSDAVP LLGTYFNCIM FMVASSVVST ILILNYHHRN ADTHEMSEWI RVVFLCWLPW
ILRMHRPGRP IIMDFTSTPC SDTSSERKHQ ILSDVELKER SSKSLLANVL DIDDDFRNVR
PMTPGGTLPH NPAFYRTVYG YLENLQGDDG SIGPIGSTRM PDAVTHHTCI KTQTEYELSL
ILKEIRFITD QLRKEDEENG IANDWKFAAM VVDRLCLIIF TMFAILATIA VLLSAPHVIV
S
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