ID A9Y024_9HEXA Unreviewed; 170 AA.
AC A9Y024;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Phosphatidylinositol 4-kinase type 2 {ECO:0000256|RuleBase:RU367084};
DE EC=2.7.1.67 {ECO:0000256|RuleBase:RU367084};
DE Flags: Fragment;
OS Podura aquatica (water springtail).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Collembola;
OC Poduromorpha; Poduroidea; Poduridae; Podura.
OX NCBI_TaxID=50589 {ECO:0000313|EMBL:ABW04846.1};
RN [1] {ECO:0000313|EMBL:ABW04846.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Paq {ECO:0000313|EMBL:ABW04846.1};
RX PubMed=19085333; DOI=10.1080/10635150802570791;
RA Regier J.C., Shultz J.W., Ganley A.R., Hussey A., Shi D., Ball B.,
RA Zwick A., Stajich J.E., Cummings M.P., Martin J.W., Cunningham C.W.;
RT "Resolving arthropod phylogeny: exploring phylogenetic signal within 41 kb
RT of protein-coding nuclear gene sequence.";
RL Syst. Biol. 57:920-938(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|RuleBase:RU367084};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367084};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU367084}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00008941,
CC ECO:0000256|RuleBase:RU367084}.
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DR EMBL; EU026232; ABW04846.1; -; mRNA.
DR AlphaFoldDB; A9Y024; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR039756; Lsb6/PI4K2.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR PANTHER; PTHR12865:SF1; PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2; 1.
DR PANTHER; PTHR12865; PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|RuleBase:RU367084};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|RuleBase:RU367084, ECO:0000313|EMBL:ABW04846.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367084};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU367084};
KW Transferase {ECO:0000256|RuleBase:RU367084}.
FT DOMAIN 1..170
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABW04846.1"
FT NON_TER 170
FT /evidence="ECO:0000313|EMBL:ABW04846.1"
SQ SEQUENCE 170 AA; 19798 MW; AE871EC0A4DD28F0 CRC64;
GRSCLVPNQG YLSEAGASLV DQKLQLNVVP KTKVVGLVSE TFNYLRIDRE KARAKRAVFE
RFPVLGRRFH RIGLPPKKGS FQLFVEGYKD ADYWLRRFET EPLTESVDRE FQLQFERLVV
LDYIIRNTDR GNDNWLIKYE KPDVRESVDE EWNVVRPPEI RVAAIDNGLA
//
