ID ABHEA_DANRE Reviewed; 270 AA.
AC Q1LV46; Q6NZ71;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Protein ABHD14A {ECO:0000305};
DE EC=3.-.-.-;
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 14A {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 14A {ECO:0000250|UniProtKB:Q9BUJ0};
GN Name=abhd14a {ECO:0000250|UniProtKB:Q9BUJ0};
GN ORFNames=si:ch211-231a1.1, zgc:85972;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possible role in granule neuron development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305};
CC Single-pass type II membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD14 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH66291.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX908398; CAK04596.1; -; Genomic_DNA.
DR EMBL; BC066291; AAH66291.1; ALT_INIT; mRNA.
DR RefSeq; NP_996949.2; NM_207066.2.
DR AlphaFoldDB; Q1LV46; -.
DR SMR; Q1LV46; -.
DR STRING; 7955.ENSDARP00000075671; -.
DR ESTHER; danre-abhea; CIB-CCG1-interacting-factor-B.
DR MEROPS; S33.981; -.
DR GlyCosmos; Q1LV46; 2 sites, No reported glycans.
DR PaxDb; 7955-ENSDARP00000109466; -.
DR GeneID; 404598; -.
DR KEGG; dre:404598; -.
DR AGR; ZFIN:ZDB-GENE-040426-2428; -.
DR CTD; 25864; -.
DR ZFIN; ZDB-GENE-040426-2428; abhd14a.
DR eggNOG; ENOG502QR0B; Eukaryota.
DR HOGENOM; CLU_020336_28_2_1; -.
DR InParanoid; Q1LV46; -.
DR OMA; GWSFNAD; -.
DR OrthoDB; 2963153at2759; -.
DR PhylomeDB; Q1LV46; -.
DR TreeFam; TF314465; -.
DR PRO; PR:Q1LV46; -.
DR Proteomes; UP000000437; Chromosome 22.
DR Bgee; ENSDARG00000058367; Expressed in mature ovarian follicle and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR46197:SF1; PROTEIN ABHD14A; 1.
DR PANTHER; PTHR46197; PROTEIN ABHD14B-LIKE; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Glycoprotein; Hydrolase; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..270
FT /note="Protein ABHD14A"
FT /id="PRO_0000282288"
FT TRANSMEM 9..29
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT ACT_SITE 170
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 221
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 248
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 270 AA; 29664 MW; 259A6BFFBAA59304 CRC64;
MMNFLRNRLV VLGLVLLATV LLYLLLPSMR QGSMEPSLEV QQRMGLMAAT PPPPPPPSSV
NITVRTGQLP GDPPLFFREA LPVDSAGRQI LPRLQMVLLH GQAFTSKTWE ELGTLSLLAS
SGYQALALDL PGYGNSPDSE SVKSDQSRVD LLKRFLEALG VRAPVLLSPS MSGHYALPFL
QRHSAQLHGF VPIAPVGTRG ITPQQYHDIQ TPTLIIYGEL DTNLGAQSHK NLIQLPNHTV
VKLAGARHAC YMDKPREFHR ALLDFLSKLD
//
