ID ACHD_CHICK Reviewed; 513 AA.
AC P02717;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 27-MAR-2024, entry version 162.
DE RecName: Full=Acetylcholine receptor subunit delta;
DE Flags: Precursor;
GN Name=CHRND;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6096871; DOI=10.1073/pnas.81.24.7975;
RA Nef P., Mauron A., Stalder R., Alliod C., Ballivet M.;
RT "Structure linkage, and sequence of the two genes encoding the delta and
RT gamma subunits of the nicotinic acetylcholine receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:7975-7979(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14.
RX PubMed=2311580; DOI=10.1002/j.1460-2075.1990.tb08174.x;
RA Wang X.M., Tsay H.J., Schmidt J.;
RT "Expression of the acetylcholine receptor delta-subunit gene in
RT differentiating chick muscle cells is activated by an element that contains
RT two 16 bp copies of a segment of the alpha-subunit enhancer.";
RL EMBO J. 9:783-790(1990).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000250|UniProtKB:P04759};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000250|UniProtKB:P04759};
CC -!- SUBUNIT: Pentamer of two alpha chains, and one each of the beta, delta,
CC and gamma chains.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. {ECO:0000305}.
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DR EMBL; K02903; AAB59944.1; -; Genomic_DNA.
DR EMBL; X52010; CAA36259.1; -; Genomic_DNA.
DR PIR; A03176; ACCHD1.
DR AlphaFoldDB; P02717; -.
DR SMR; P02717; -.
DR ComplexPortal; CPX-254; Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma.
DR STRING; 9031.ENSGALP00000054388; -.
DR GlyCosmos; P02717; 2 sites, No reported glycans.
DR PaxDb; 9031-ENSGALP00000012809; -.
DR VEuPathDB; HostDB:geneid_424940; -.
DR eggNOG; KOG3645; Eukaryota.
DR InParanoid; P02717; -.
DR PhylomeDB; P02717; -.
DR Proteomes; UP000000539; Unassembled WGS sequence.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19028; LGIC_ECD_nAChR_D; 1.
DR CDD; cd19064; LGIC_TM_nAChR; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF61; ACETYLCHOLINE RECEPTOR SUBUNIT DELTA; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Phosphoprotein;
KW Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..18
FT CHAIN 19..513
FT /note="Acetylcholine receptor subunit delta"
FT /id="PRO_0000000325"
FT TOPO_DOM 19..244
FT /note="Extracellular"
FT TRANSMEM 245..269
FT /note="Helical"
FT TRANSMEM 277..295
FT /note="Helical"
FT TRANSMEM 311..332
FT /note="Helical"
FT TOPO_DOM 333..467
FT /note="Cytoplasmic"
FT TRANSMEM 468..490
FT /note="Helical"
FT MOD_RES 388
FT /note="Phosphotyrosine; by Tyr-kinases"
FT /evidence="ECO:0000250"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 148..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 513 AA; 59011 MW; 0C35772CC57E12CF CRC64;
MAVLLALFGA LVLSGGLCVN QEERLIHHLF EERGYNKEVR PVASADEVVD VYLALTLSNL
ISLKEVDETL TTNVWVEQSW TDYRLQWNTS EFGGVDVLRL LPEMLWLPEI VLENNNDGLF
EVAYYCNVLV YNTGYVYWLP PAIFRSACPI NVNFFPFDWQ NCTLKFSSLA YNAQEINMHL
KEESDPETEK NYRVEWIIID PEGFTENGEW EIIHRPARKN IHPSYPTESS EHQDITFYLI
IKRKPLFYVI NIVTPCVLIA FMAILVFYLP ADSGEKMTLV ISVLLAQSVF LLLVSQRLPA
TSHAIPLIGK YLLFIMLLVT AVVVICVVVL NFHFRTPSTH VMSDWVRGVF LEILPRLLHM
SHPAESPAGA PCIRRCSSAG YIAKAEEYYS VKSRSELMFE KQSERHGLAS RVTPARFAPA
ATSEEQLYDH LKPTLDEANF IVKHMREKNS YNEEKDNWNR VARTLDRLCL FLITPMLVVG
TLWIFLMGIY NHPPPLPFSG DPFDYREENK RYI
//
