ID ACS3_RUTGR Reviewed; 391 AA.
AC Q9FSC2;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Probable acridone synthase 3;
DE EC=2.3.1.159;
DE AltName: Full=Acridone synthase III;
GN Name=ACS3;
OS Ruta graveolens (Common rue).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Rutoideae; Ruta.
OX NCBI_TaxID=37565;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Immature flower;
RA Springob K., Matern U.;
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-
CC dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O;
CC Xref=Rhea:RHEA:22224, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:30306, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:58630; EC=2.3.1.159;
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000305}.
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DR EMBL; AJ297786; CAC14056.2; -; mRNA.
DR PIR; S60241; S60241.
DR AlphaFoldDB; Q9FSC2; -.
DR SMR; Q9FSC2; -.
DR GO; GO:0050635; F:acridone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF14; CHALCONE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Flavonoid biosynthesis; Transferase.
FT CHAIN 1..391
FT /note="Probable acridone synthase 3"
FT /id="PRO_0000216088"
FT ACT_SITE 164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ SEQUENCE 391 AA; 42726 MW; C00A63095CEA8B93 CRC64;
MESLKEMRKA QMSEGPAAIL AIGTANPDNV YMQADYPDYY FKMTKSEHMT ELKDKFRTLC
EKSMIRKRHM CFSEEFLKAN PEVCKHMGKS LNARQDIAVV ETPRLGNEAA VKAIKEWGQP
KSSITHLIFC SSAGVDMPGA DYQLTRILGL NPSVKRMMIY QQGCYAGGTV LRLAKDLAEN
NKGSRVLVVC SELTAPTFRG PSPDAVDSLV GQALFADGAA ALVVGADPDS SIERALYYLV
SASQMLLPDS DGAIEGHIRE EGLTVHLKKD VPALFSGNID TPLVEAFKPL GISDWNSIFW
IAHPGGPAIL DQIEEKLGLK EDKLRASKHV MSEYGNMSSS CVLFVLDEMR SRSLQDGKST
TGEGLDWGVL FGFGPGLTVE TIVLRSVPIE A
//
