ID ARIP4_XENTR Reviewed; 1396 AA.
AC A4IHD2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Helicase ARIP4;
DE EC=3.6.4.12;
DE AltName: Full=Androgen receptor-interacting protein 4;
DE AltName: Full=RAD54-like protein 2;
GN Name=rad54l2; Synonyms=arip4;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA helicase that modulates androgen receptor (AR)-dependent
CC transactivation in a promoter-dependent manner. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important
CC for the association with nuclear receptors. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. {ECO:0000305}.
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DR EMBL; BC135473; AAI35474.1; -; mRNA.
DR RefSeq; NP_001076824.1; NM_001083355.1.
DR RefSeq; XP_012816701.1; XM_012961247.2.
DR RefSeq; XP_012816702.1; XM_012961248.2.
DR RefSeq; XP_012816703.1; XM_012961249.2.
DR AlphaFoldDB; A4IHD2; -.
DR SMR; A4IHD2; -.
DR STRING; 8364.ENSXETP00000009619; -.
DR PaxDb; 8364-ENSXETP00000000131; -.
DR Ensembl; ENSXETT00000000131; ENSXETP00000000131; ENSXETG00000000070.
DR GeneID; 733747; -.
DR KEGG; xtr:733747; -.
DR AGR; Xenbase:XB-GENE-5829376; -.
DR CTD; 23132; -.
DR Xenbase; XB-GENE-5829376; rad54l2.
DR eggNOG; KOG1016; Eukaryota.
DR InParanoid; A4IHD2; -.
DR OMA; ICNEYSN; -.
DR OrthoDB; 12329at2759; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Bgee; ENSXETG00000000070; Expressed in 4-cell stage embryo and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18069; DEXHc_ARIP4; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.20.120.850; SWI2/SNF2 ATPases, N-terminal domain; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR044574; ARIP4-like.
DR InterPro; IPR044573; ARIP4_DEXHc.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45797:SF1; HELICASE ARIP4; 1.
DR PANTHER; PTHR45797; RAD54-LIKE; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW Reference proteome; Repeat.
FT CHAIN 1..1396
FT /note="Helicase ARIP4"
FT /id="PRO_0000315783"
FT DOMAIN 290..510
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 717..891
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1194..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 461..464
FT /note="DEAH box"
FT MOTIF 549..553
FT /note="LXXLL motif 1"
FT MOTIF 1273..1277
FT /note="LXXLL motif 2"
FT COMPBIAS 10..49
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 303..310
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1396 AA; 156367 MW; 79566FD319FAA98B CRC64;
MSDASISGSE PELDPEDMEE EEEDDEDDDE EEEEEEDEED NDGDDEDDKQ DINEKSQNAA
LGEDSPEQGE EGWKRSTTSG QSGQESDEAK KKRLQKPANL RRNIRKLLRE DQLESVTKTA
QQEELERRKR LEQQRKDYPL PLTLPPVSLD FLQEEIELRA ADVSQLVKSQ EIICLDSSSG
ESDDEGKVKS HSIKDEIIEL SSGEEDNLQI SDNADSTNEV DGDITTENSG SHVNDALNQA
DHLGRVLVNI NHPPNEKDIF LAPQLARAVK SHQIGGIRFL YDNLVESLER FSGSSGFGCI
LAHSMGLGKT LQVISFLDVL FQHTSAKTVL AIVPVNTLQN WLAEFNMWLP PPESLPKDHN
QELVQPRAFK VHTMNDEHKT TAARAKVVND WATDGGVLLM GYEMYRLLSL KKSFTAGRKK
KSKKAAGPVI IDLDEEDRQQ EMLKGIEKAL SRPGPDVVIC DEGHRIKNCH ASTSQALKNI
RSRRRVVLTG YPLQNNLIEY WCMVDFVRPD FLGTRQEFSN MFERPILNGQ CVDSTPQDKR
LMRYRSHVLH SLLEGFVQRR GHTVLKAQLP FKEEHVILVR LSKIQRDLYT EFMNRFRDAG
NSGWLGLNPL KAFCVCCKIW NHPDVLYEAL QKENLANEQD LDVEDLGTNN RCNAQSGKIK
VEPNSLGALM GETAHTKQLQ GIVLNPSHEK ANQVVTYEWA KEILSDYIPG QLQNSPKMVL
LFHLIEESMR MGDKILVFSQ SLSTLSIMEE FLAKRKMPIP AGSDGQEGHT WIRNVNYYRL
DGSTSASERE RLINQFNDPS NEKVWLFLLS TRAGCLGVNL IGANRVVVFD ASWNPCHDAQ
AVCRVYRYGQ RKPCYIYRLV SDFTLEKKIY DRQITKQGMS DRVVDDLNPE VNFTRREVEN
LLHFVEEEPD ASRQHLDSSS FHEAVLQKAC LQYPHLITKE PFQHESLLLD RKEQKLTLAE
KKAAKRGYEE EKRASVPYTR PSYTQYYPAP DHNLGNIPAF SQRHWRPLMK GDDRPVASVR
PLQSTPIPML PRHVSVNHPG SASASVHPYN FPVNYLQRAG VLVQKVVTTT DIVIPGMTTS
TDVQARISAG ESIHVIRGTK GTYIRTSDGR IFAIRASGKQ KSGEVRRQAT SGAQGSSAPY
LSNGRHSTSS PSQQDSEDPP RPLSPDSPEI LNELQKYADA AAARGSHTAP QLQNLGLHHQ
GINPAPKLQP RKRKDPQDQS SHWPSNKRNP YSQLSYPNTG GFGVTPSTMN HNLVRSSNPV
FMGPGGGSSH FQLPSLLSDP QTGLPLVQDS LLTHSSGTSS APSVPPHYLL PRGFPLPFSQ
SLLPQTRMFA PYPSQILNRG LPTNNPASTF PGYLSSHSNY QASPGTSSRP LPSGETELGS
CEEDGRDDDV VEVTGE
//
