ID B0BML4_XENTR Unreviewed; 122 AA.
AC B0BML4;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=SNARE-associated protein Snapin {ECO:0000256|PIRNR:PIRNR037631};
DE AltName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 7 {ECO:0000256|PIRNR:PIRNR037631};
GN Name=snapin {ECO:0000313|Ensembl:ENSXETP00000112365,
GN ECO:0000313|RefSeq:NP_001120066.1,
GN ECO:0000313|Xenbase:XB-GENE-5915889};
GN Synonyms=LOC100145066 {ECO:0000313|EMBL:AAI58481.1}, snapap
GN {ECO:0000313|RefSeq:NP_001120066.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI58481.1};
RN [1] {ECO:0000313|RefSeq:NP_001120066.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI58481.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testes {ECO:0000313|EMBL:AAI58481.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000112365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000112365};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000112365}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2021) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001120066.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. In concert with the AP-3
CC complex, the BLOC-1 complex is required to target membrane protein
CC cargos into vesicles assembled at cell bodies for delivery into
CC neurites and nerve terminals. The BLOC-1 complex, in association with
CC SNARE proteins, is also proposed to be involved in neurite extension.
CC Plays a role in intracellular vesicle trafficking and synaptic vesicle
CC recycling. {ECO:0000256|PIRNR:PIRNR037631}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000256|PIRNR:PIRNR037631}.
CC -!- SIMILARITY: Belongs to the SNAPIN family.
CC {ECO:0000256|ARBA:ARBA00006111, ECO:0000256|PIRNR:PIRNR037631}.
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DR EMBL; BC158480; AAI58481.1; -; mRNA.
DR RefSeq; NP_001120066.1; NM_001126594.1.
DR Ensembl; ENSXETT00000109474; ENSXETP00000112365; ENSXETG00000044724.
DR GeneID; 100145066; -.
DR KEGG; xtr:100145066; -.
DR CTD; 23557; -.
DR Xenbase; XB-GENE-5915889; snapin.
DR HOGENOM; CLU_3019721_0_0_1; -.
DR OMA; HLHIAKT; -.
DR OrthoDB; 3785351at2759; -.
DR Reactome; R-XTR-432722; Golgi Associated Vesicle Biogenesis.
DR Proteomes; UP000008143; Chromosome 8.
DR GO; GO:0031083; C:BLOC-1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR InterPro; IPR017246; Snapin.
DR InterPro; IPR028119; Snapin/Pallidin/Snn1.
DR PANTHER; PTHR31305; SNARE-ASSOCIATED PROTEIN SNAPIN; 1.
DR PANTHER; PTHR31305:SF2; SNARE-ASSOCIATED PROTEIN SNAPIN; 1.
DR Pfam; PF14712; Snapin_Pallidin; 1.
DR PIRSF; PIRSF037631; Snapin; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037631};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR037631};
KW Membrane {ECO:0000256|PIRNR:PIRNR037631};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Synapse {ECO:0000256|PIRNR:PIRNR037631}.
FT REGION 98..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 122 AA; 13781 MW; 2DB27457ADB84C75 CRC64;
MAVSPGRDVF AEGLLELLKP AVQQLDSHVH AVRESQVDLR EHIDNLASEL CKINEDQKVA
LDLDPYVKKL LNARRRVVLV NNILQNAQER LRRLNHSVAK ETARRRAMLD SGSHHPPASP
NK
//
