ID B0C148_ACAM1 Unreviewed; 573 AA.
AC B0C148;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=DNA mismatch repair protein MutL {ECO:0000313|EMBL:ABW28446.1};
GN Name=mutL {ECO:0000313|EMBL:ABW28446.1};
GN OrderedLocusNames=AM1_3452 {ECO:0000313|EMBL:ABW28446.1};
OS Acaryochloris marina (strain MBIC 11017).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Acaryochloridales;
OC Acaryochloridaceae; Acaryochloris.
OX NCBI_TaxID=329726 {ECO:0000313|EMBL:ABW28446.1, ECO:0000313|Proteomes:UP000000268};
RN [1] {ECO:0000313|EMBL:ABW28446.1, ECO:0000313|Proteomes:UP000000268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MBIC 11017 {ECO:0000313|Proteomes:UP000000268};
RX PubMed=18252824; DOI=10.1073/pnas.0709772105;
RA Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J.,
RA Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D.,
RA Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y.,
RA Taylor H.L., Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M.,
RA Blankenship R.E., Touchman J.W.;
RT "Niche adaptation and genome expansion in the chlorophyll d-producing
RT cyanobacterium Acaryochloris marina.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CP000828; ABW28446.1; -; Genomic_DNA.
DR RefSeq; WP_012163844.1; NC_009925.1.
DR AlphaFoldDB; B0C148; -.
DR STRING; 329726.AM1_3452; -.
DR KEGG; amr:AM1_3452; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_3; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000000268; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000000268}.
FT DOMAIN 219..346
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 399..521
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 573 AA; 64317 MW; DDDDD257192B9E7B CRC64;
MVECAPDLQI QPLGTDLVHR IAAGEVIDSL GAVVRELLDN ALDAGADRIS VSLWPQDWRI
QVVDNGQGLT AANLAQAATP HTTSKLQREE DLWDIQTLGF RGEALHSLAQ MGRLEICSRP
VGSAQGCRVR YDHQGHVVAQ ETVAIAPGTV ATVADLFQDW PTRKQALPDP ARQMRGVQTI
IHDYALCHPQ VTWQVQQNNR LWFSIAPAKA AQDILPQLLA TLQPGDLCHH RCQIPDLPGN
NVVEVVLGLP DRCHRHRPDW VKVAVNGRCV QVSGEDAGQS HPLEQTILGA FRQTLPRHRH
PLCFIHLHAD PQHVDWHRHP AKTEIYLRHL DQWRPAVTTT IQEALQIPAE IQDSGHTQKI
RQLMKVAEAK GVYHLQQPSL LSSQPEQAAG ESGFNVLKAI AQLHRTYIVA EHPSGVWLVE
QHIAHERVLY EQLGQDWHLV PLTPPMMLRD LTERQVEQLT DIGIDITEFG HQLWAIRSAP
QRLAERPDCE AALIELSQCE SIEAALAATA CRSAIRNGMA LNLLEMQNLL DQWQQTRHPR
TCPHGRPIYL SMEEADLSRF FRRHWVIGKS HGI
//
