ID   B0E6W9_ENTDS            Unreviewed;       935 AA.
AC   B0E6W9;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=T-cell activation Rho GTPase activating protein, putative {ECO:0000313|EMBL:EDR29710.1};
DE            EC=2.7.11.1 {ECO:0000313|EMBL:EDR29710.1};
GN   ORFNames=EDI_251460 {ECO:0000313|EMBL:EDR29710.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS547933; EDR29710.1; -; Genomic_DNA.
DR   RefSeq; XP_001734129.1; XM_001734077.1.
DR   AlphaFoldDB; B0E6W9; -.
DR   EnsemblProtists; EDR29710; EDR29710; EDI_251460.
DR   GeneID; 5879026; -.
DR   KEGG; edi:EDI_251460; -.
DR   VEuPathDB; AmoebaDB:EDI_251460; -.
DR   eggNOG; KOG4724; Eukaryota.
DR   OMA; SNMSCHL; -.
DR   OrthoDB; 11483at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23179:SF3; RHO GTPASE ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Transferase {ECO:0000313|EMBL:EDR29710.1}.
FT   DOMAIN          311..499
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          615..791
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          45..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..70
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   935 AA;  108132 MW;  CBF29FA9A6906E21 CRC64;
     MSSHNQSPGV DQLLVTAVRR PKPMQHNNNS VKQLSEDILL ELRKKKGEKT PRTRRRTLAV
     DKKSVASEND QSESEESIIQ NIANEIEALQ NEIKVARDKC LKIMEGQQQF KILIDSLSNQ
     RKVVLDMKEN LRDITIRDVG SRSDVEECSE FMGELYLKCF DQFNEQIRST EGFYETIKKY
     IDSCSNFTRA RNDFDKLISS YATVDMKLQK MNKEKRPDIN KVGQLQQQKE ETFNSIKSEG
     EKVTDFYVDL YNEFLTIMLH TSVDLSDKVS KGLTSTKRMF KDKGEKLNLW KTLNIGEAVK
     NADVEYPQWM DDDPLFINIF EAENHLVEKM EYCVVKYAKS LLCNPTLATT GMSMADVNLI
     FTEIESIHSL HHSIFTELKN STIDSFIDAF AKRASQLYDV YKRRCAHFKD SMKKYNKCLQ
     IEAFKDAIES IDNSNLSQPR LEELLHLPFI HLTQLVPLFN SLKDDFSEET DKTEKLEELC
     FIFTSLSLLS EQAEKENDVE TQLSKINGLK GISFSPKRKY LDRQQCTYNK TQGTMFLFND
     IFIFTKPERN EYIFGSVIDV SQMVSFRVKN KKVVALEIKN ETCDIGFKDT QTAEKCAKYL
     NSIKYEMDRK KIFGTEIKSS VIAREEENTL IPSVIHKIFD KLEKEAPDTE GIFRISVSVK
     DLEETMTKID LDVNIDVSNM SCHLLGNVLK KYLNLMPNKL PISLQTVDVD NIKAIQDILE
     PVGKSYLLLM ERLFRLLQMI DKNSGVNKMT ADNLAKVICP NIYEEDDDFG MNIEKLTRTA
     IVMIQRYDEI FGDFRSAIEK KIQEGMQEIN HQKELEAKIQ SEDGFKEIPV SKLVEGHQDD
     KTVVLTLKDI IKQGDVEMLE GKKWGKKWVV MKKNCLMIFR NIGEGQTLMV LPFKNMIVAT
     ETKMNRECII LRVEKQSVTL YFEDPNEWLQ LFSSF
//