ID B0E966_ENTDS Unreviewed; 444 AA.
AC B0E966;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Serine/threonine protein kinase HT1, putative {ECO:0000313|EMBL:EDR28940.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:EDR28940.1};
GN ORFNames=EDI_072490 {ECO:0000313|EMBL:EDR28940.1};
OS Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN [1] {ECO:0000313|Proteomes:UP000008076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT "Annotation of Entamoeba dispar SAW760.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS548292; EDR28940.1; -; Genomic_DNA.
DR RefSeq; XP_001734894.1; XM_001734842.1.
DR AlphaFoldDB; B0E966; -.
DR EnsemblProtists; EDR28940; EDR28940; EDI_072490.
DR GeneID; 5879823; -.
DR KEGG; edi:EDI_072490; -.
DR VEuPathDB; AmoebaDB:EDI_072490; -.
DR eggNOG; KOG0192; Eukaryota.
DR OMA; RPDYKIV; -.
DR OrthoDB; 22545at2759; -.
DR Proteomes; UP000008076; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR45756; PALMITOYLTRANSFERASE; 1.
DR PANTHER; PTHR45756:SF1; SERINE_THREONINE-PROTEIN KINASE DDB_G0278665-RELATED; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EDR28940.1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:EDR28940.1};
KW Transferase {ECO:0000313|EMBL:EDR28940.1}.
FT DOMAIN 142..439
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 306
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 326
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 444 AA; 50008 MW; 479CFEDE0CA2D259 CRC64;
MSLSKGSRTS SVGSCAQLKF PFEIEPPIQK LTFGREYAVQ GVSMKQKITF HNKTTDAYKM
TVELSTSSKY TMEADEEKLT IGKRSKKSVT ISICFNTIAT VGLTGSVTFQ VKKKVLIGSE
SSSLALRFQM LGVIPIVNMK EINLIKKINK SSANSIIKEK TGSSHIAIRE NTCTTETNSV
DLSTLTMGLN DSVSVGDVIG KHGKYKEDNV FIFKLDTKES RLTKEDFKVI LNNYIDIHHQ
NIIQMVGMNY DSSLLLLEND TMFNLEQILE KPLPSLFLTR CCVNLATALQ YLASENILHR
NVKPFNLRLV QHSTIFLGGP LVKLHDFSLA RYVHEGEELN DYVGTMEYMS PEIIQHKSYG
LKSDTFSLGM SILHIFSGKK PYRGMNKQQI EKFVKNHQRI NPSEKVPIAI ISIINKCCVE
DPTKRPDYKI VINLLNDYAR TLPL
//
