ID   B0EDZ0_ENTDS            Unreviewed;       866 AA.
AC   B0EDZ0;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Heat shock protein, putative {ECO:0000313|EMBL:EDR27269.1};
DE            EC=3.4.21.53 {ECO:0000313|EMBL:EDR27269.1};
GN   ORFNames=EDI_344750 {ECO:0000313|EMBL:EDR27269.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; DS548877; EDR27269.1; -; Genomic_DNA.
DR   RefSeq; XP_001736499.1; XM_001736447.1.
DR   AlphaFoldDB; B0EDZ0; -.
DR   EnsemblProtists; EDR27269; EDR27269; EDI_344750.
DR   GeneID; 5881489; -.
DR   KEGG; edi:EDI_344750; -.
DR   VEuPathDB; AmoebaDB:EDI_344750; -.
DR   eggNOG; KOG1051; Eukaryota.
DR   OMA; HDERESI; -.
DR   OrthoDB; 35211at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF190; CLP R DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:EDR27269.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}; Stress response {ECO:0000313|EMBL:EDR27269.1}.
FT   DOMAIN          3..145
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   COILED          411..529
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   866 AA;  98179 MW;  48EF12C73174E349 CRC64;
     MDPNKWTDAT VQMFKESQEI AFERKNAYIM PIHMMEAIVE EESNIVIRIV EMMGGDVNKL
     KKEIKETMNK IPVQNPPPVD IGLHPTTQQV LRRAIEKQKR MGDSYLAIDV IVMSLMEEKE
     ISTIVGNSGI NVKEFNKKIT EMRKGQSVET KEAESQYEAL KKYGNDLTAQ AESGKMDPII
     GRDEEIKRVI RILSRRTKNN PVLIGEPGVG KTAVVEGLAQ RIVKGDVPSN LQCRVIGLDM
     GALIAGAQYR GQFEERLKAV IKEVKESKIP IILFIDEIHT VLGAGATGEG AMDAANILKP
     MLSRGELRCI GATTLEEYRK YVEKDPAFER RFQQVYVKEP SEEDTLYILR GIREKYENHY
     GLTITDSALV SAATLSKRYI NGRFLPDKAI DLVDEACATL FTQKNSQPEE IDKLERRETQ
     LNVEKIALER DIKESDEDHN KMIKERLQEI EKELSENKEK LTKLRINYEK EKGGSEEMKE
     LATKIEAMKH KAESTKDLEV AADLKYYAIP EAEKRMKELK EQNKETTMIS LQVTPTQIEE
     VVSRWTGIPV TKMNQTEKTR LMNLEEELHK RVIGQNEAVT AVSDAIIRSR GGLGNEKRPT
     GSFMFLGPSG VGKTELAKAL AVELFDDEQN IVRIDMSEYM ESHSVSRLIG APPGYVGYEE
     GGQLTEAIRR KPYSVILFDE IEKAHPQVFN VLLQLLDEGR LTDGRGRTVD FKNTIVIMTS
     NLGSEIIMKG VETEGQVSRK VKETVMEIVK KTFKPEFLNR LDDIIVFSPL SEKELKEIVK
     LQMGEVIKMI KKRYPLSEVE MTEAAIEGII KSGYSIAYGA RPMRRYIEKT VVTSITKSII
     SGIMKEKNKI QIDYENDKIQ VKITDK
//