ID   B0EHV0_ENTDS            Unreviewed;       535 AA.
AC   B0EHV0;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN   ORFNames=EDI_044500 {ECO:0000313|EMBL:EDR25894.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000256|ARBA:ARBA00037092}.
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DR   EMBL; DS549356; EDR25894.1; -; Genomic_DNA.
DR   RefSeq; XP_001737803.1; XM_001737751.1.
DR   AlphaFoldDB; B0EHV0; -.
DR   EnsemblProtists; EDR25894; EDR25894; EDI_044500.
DR   GeneID; 5882857; -.
DR   KEGG; edi:EDI_044500; -.
DR   VEuPathDB; AmoebaDB:EDI_044500; -.
DR   eggNOG; KOG4270; Eukaryota.
DR   OMA; NDLMKSH; -.
DR   OrthoDB; 25175at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR   PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
FT   DOMAIN          337..535
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          88..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   535 AA;  62093 MW;  9611515016D33559 CRC64;
     MNPTLATPRR TRPKVMDLRF TPREDNQENN QQLVMLKANK QNFLNPPILN QLGELENSIF
     CLFYLKNANH FVKSKFNLIR MNMLYSKSTP STPRSLNSPR SPRKKFSSPE LQEELLKYME
     KYRMIGDNFV WLSGLVSIFQ IKFSEYSQKK LIELYHSIFS VNPIITDGVN VLLSYDTINK
     KPRIIQLTKN FLFIGKEETK EIDHIIYLTN PHLILINETT IGFNNISIEF KHQDVCVKWI
     DNLTKLQPWY ATVPRSTIRK DDHSLIMFNP DITSGNRNRS SNDLMKSHGS LMPLIQKSVS
     TPNKGLSPRS KGLLSKGFIS RLSNKSKTTK IIKIVGVSLE TLSVENNIIT LPPNISLLIQ
     YLKKHAITIE GIFRVSGSKD NIQKVVEKLD TKMMTFECLT NFDIHSVAGA LKLYIKLLPE
     QVIPKFIDDR LYELWKQKNT LQEDDLFQQF HEIYKDIPPM TYNFLNELLD LLHLIAMNKE
     ITKMNIENCV TCLAPSLRGY PFVYTYSIQH YSQLFPKEIH NQTKEKTIEE SNTTM
//