ID B0EI53_ENTDS Unreviewed; 243 AA.
AC B0EI53;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Arf GTPase-activating protein, putative {ECO:0000313|EMBL:EDR25794.1};
DE EC=2.4.1.119 {ECO:0000313|EMBL:EDR25794.1};
GN ORFNames=EDI_069980 {ECO:0000313|EMBL:EDR25794.1};
OS Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN [1] {ECO:0000313|Proteomes:UP000008076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT "Annotation of Entamoeba dispar SAW760.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the DDOST 48 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00008743}.
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DR EMBL; DS549398; EDR25794.1; -; Genomic_DNA.
DR RefSeq; XP_001737904.1; XM_001737852.1.
DR AlphaFoldDB; B0EI53; -.
DR EnsemblProtists; EDR25794; EDR25794; EDI_069980.
DR GeneID; 5882959; -.
DR KEGG; edi:EDI_069980; -.
DR VEuPathDB; AmoebaDB:EDI_069980; -.
DR eggNOG; KOG0706; Eukaryota.
DR eggNOG; KOG2754; Eukaryota.
DR OrthoDB; 1356at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000008076; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0018279; P:protein N-linked glycosylation via asparagine; IEA:InterPro.
DR CDD; cd08830; ArfGap_ArfGap1; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR005013; DDOST_48_kDa_subunit.
DR PANTHER; PTHR45686; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED; 1.
DR PANTHER; PTHR45686:SF28; GTPASE ACTIVATING PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF03345; DDOST_48kD; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosyltransferase {ECO:0000313|EMBL:EDR25794.1};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}; Transferase {ECO:0000313|EMBL:EDR25794.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..95
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
SQ SEQUENCE 243 AA; 28117 MW; C6F7A8F553B41F37 CRC64;
MSTEKVVLSN TRRDAIFKQL KTKNGNNYCF ECGTPNPSWA SVPYGIFICI QCSGKHRGLG
VHLSFVRSID MDTWTDKQMS NMINGGNDKM KNSWEKINGV KEVNYDHQLV INDTIKVNVE
LEQLDQGNYV PFNVDDLQIE LKLLDPVIVK NFKRINNGKY EVIVQTPDKF GVYTMVINYR
RPFLSYLEYK ETIPLRTFRL TQVDRFLTGA YPFYAACASM AIGFIVFSFI YLNQIEKKEI
KQD
//
