ID B0EN51_ENTDS Unreviewed; 382 AA.
AC B0EN51;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EDR24047.1};
DE EC=2.7.11.1 {ECO:0000313|EMBL:EDR24047.1};
GN ORFNames=EDI_140520 {ECO:0000313|EMBL:EDR24047.1};
OS Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN [1] {ECO:0000313|Proteomes:UP000008076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT "Annotation of Entamoeba dispar SAW760.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS550053; EDR24047.1; -; Genomic_DNA.
DR RefSeq; XP_001739573.1; XM_001739521.1.
DR AlphaFoldDB; B0EN51; -.
DR EnsemblProtists; EDR24047; EDR24047; EDI_140520.
DR GeneID; 5884708; -.
DR KEGG; edi:EDI_140520; -.
DR VEuPathDB; AmoebaDB:EDI_140520; -.
DR eggNOG; KOG4424; Eukaryota.
DR OMA; PVTEMMD; -.
DR OrthoDB; 22806at2759; -.
DR Proteomes; UP000008076; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF267; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13320)-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Transferase {ECO:0000313|EMBL:EDR24047.1}.
FT DOMAIN 12..198
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
SQ SEQUENCE 382 AA; 44613 MW; B5F364B54001FC90 CRC64;
MLYSKEEKRY LYCGNVVKEF ITTENTYCEQ LGVVENLIHQ PLIKQEKPLL TPEQIKLIFG
GVSVIYGVNT ALLQNLREKL SVYTQSSRFG HIVLTFTPLL RVYSDYCQTY PQVSQLVSSM
KVPHPFGTFY KLQMKQAPEH LQRFDLLSLL ITPIQRLPRY RLLLKDLLKH LRPSDIDYED
VKKALNEIEK VTSFVNTQSK KQENMEKVVN LYSQIKGIPE DIQLIQPGRE LINSTSVLMK
QKYVQLTDNG KEIAVLTIPL FNQMKKEPNN LLIKTPTITT NFIEKEMPVD IILFTDIILF
VEKNKSLFSG ETLQFRLVIN IGDAAIFRNN NEIQIRYSEE TIKLIFADKE NEDLWYNILS
DTFVHCHDII QNLQQRRKSL RY
//
