ID   B0EUS9_ENTDS            Unreviewed;       519 AA.
AC   B0EUS9;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=EDI_161880 {ECO:0000313|EMBL:EDR21723.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS550966; EDR21723.1; -; Genomic_DNA.
DR   RefSeq; XP_001741814.1; XM_001741762.1.
DR   AlphaFoldDB; B0EUS9; -.
DR   EnsemblProtists; EDR21723; EDR21723; EDI_161880.
DR   GeneID; 5886747; -.
DR   KEGG; edi:EDI_161880; -.
DR   VEuPathDB; AmoebaDB:EDI_161880; -.
DR   eggNOG; ENOG502RGJZ; Eukaryota.
DR   OMA; AFMIQVD; -.
DR   OrthoDB; 21609at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
FT   DOMAIN          187..365
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
SQ   SEQUENCE   519 AA;  60274 MW;  E0142D1053251E80 CRC64;
     MKQLSIKTEN PLQTLHRSIT SEELKKRRRA ERFDCPSCIE MQGYISVLEE IIQKKNTLIS
     KLINEKEVYK IFDELRQAND PSIYAEDTIE ALLSFIDNRS IETKNKVMKK WEVMLQSRIS
     NENKKVLKSF VRNKVKTKYQ YIDIGDETTT ESDAQDDSTI LGPLDGMDYN RCDQPKPKIN
     EQLFGCLVDD FTSSQILYYQ QFQILTQLFI SPLRNLLMAK ESIKLLDKLI PPIMMVERKV
     SRCLQLKDET MWQTIKECIS EMKVYIPYIS TLKTTNIKAD IVECCMSKEF KKEQQPLIAN
     FCNKNGSQQL LPVTVYLEAP LQRFFKYPKI FGNLLSSVDP KHHDYAVITS CYLNINKMVK
     KLGDYQTNQE EQKKVIKLSH LFKQTQTQIL KDGRKLLYYG PLKIIEEKNE WNMCFLFNDI
     FVISKAIVIG ALGLEKESLM RFENAPSGTD LSSLTPYNFN EILCISLTHF LLKKVVDCNT
     ATNAFMIQVD SLQLHCCCVS VKERHNWIDS LLLTQNGSY
//