ID B0FAM7_9HIV1 Unreviewed; 345 AA.
AC B0FAM7;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ABY63552.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABY63552.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABY63552.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=555545Y1 {ECO:0000313|EMBL:ABY63552.1};
RX PubMed=18419549; DOI=10.1086/587693;
RA Svicher V., Aquaro S., D'Arrigo R., Artese A., Dimonte S., Alcaro S.,
RA Santoro M.M., Di Perri G., Lo Caputo S., Bellagamba R., Zaccarelli M.,
RA Visco-Comandini U., Antinori A., Narciso P., Ceccherini-Silberstein F.,
RA Perno C.F.;
RT "Specific enfuvirtide-associated mutational pathways in HIV-1 Gp41 are
RT significantly correlated with an increase in CD4(+) cell count, despite
RT virological failure.";
RL J. Infect. Dis. 197:1408-1418(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; EU281708; ABY63552.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ABY63552.1};
KW Virion {ECO:0000313|EMBL:ABY63552.1}.
FT TRANSMEM 167..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..208
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 208..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 296
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:ABY63552.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABY63552.1"
SQ SEQUENCE 345 AA; 39670 MW; ED3306F1CCB13D44 CRC64;
AVTXGAVFLG FLGXAGSTMG AASLTLTVQA RQLLSGIVQQ QXNLLXAIEA QQHLLRLTVW
GIKQLQARVL AVESYLRDQQ LLGIWGCSGK LICTTAVPWN ASWSNRSLNY IWNNMTWMEW
EREIDNYTDL IYTLLEESQN QQEKNEQELL ELDKWASLWN WFDISNWLWY IKIFIMIVGG
LVGLKIIFAV LSIVNRVRQG YSPLSFQTRL PTXRGPDRPE GIEEEGGEKD RDTSGLLVTS
FLAIIWVDLR SLFLFSYRHL RDLLLIVVRI VELLGRRGWE ALKYWWNLLQ YWTQELRNSA
VSLFNAIAIA VAEGTDRIIE XGQRLCRAIL HIPVRIRQGL ERALL
//
