ID B0FWT0_9SAUR Unreviewed; 265 AA.
AC B0FWT0;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=D(1B) dopamine receptor {ECO:0000256|ARBA:ARBA00018627};
DE AltName: Full=D(5) dopamine receptor {ECO:0000256|ARBA:ARBA00042808};
DE AltName: Full=Dopamine D5 receptor {ECO:0000256|ARBA:ARBA00041538};
DE Flags: Fragment;
OS Aspidoscelis inornatus (Little striped whiptail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Teiioidea; Teiidae; Aspidoscelis; Aspidoscelis sexlineata group.
OX NCBI_TaxID=68352 {ECO:0000313|EMBL:ABY65237.1};
RN [1] {ECO:0000313|EMBL:ABY65237.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ABY65237.1};
RA Munchrath L., Crews D.;
RT "Hormonal regulation of neurotransmitter receptor expression.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC which activate adenylyl cyclase. {ECO:0000256|ARBA:ARBA00002363}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; EU358573; ABY65237.1; -; mRNA.
DR AlphaFoldDB; B0FWT0; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF136; D(1B) DOPAMINE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:ABY65237.1};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..265
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 103..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABY65237.1"
FT NON_TER 265
FT /evidence="ECO:0000313|EMBL:ABY65237.1"
SQ SEQUENCE 265 AA; 29564 MW; 58087B15F2EE63AF CRC64;
LAVTDLMVAL LVMPWKAVTE VAGYWPFGAF CNVWVAFDIM CSTASILNLC VISVDRYWAI
SSPFRYERKM TQRVALVMIG LAWALSVLIS FIPVQLNWHR GEDPHAPPAS AHPRTSRPQP
GGVSSWADEL GMVWTEVPEV QSNGTGAAEP RTEHCDSSLN RTYAISSSLI SFYIPVAIMI
VTYTRIYQIA QVQIRRISSL ERAAEHAQSC RSSCSSGGKR LPCPYHHHHH PCLKSSIRKE
TKVLKTLSVI MGVFVCCWLP FFIVA
//
