ID   B0FYI0_9GAMM            Unreviewed;      4370 AA.
AC   B0FYI0;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Peptide synthetase {ECO:0000313|EMBL:ABY71213.1};
OS   Pseudoalteromonas sp. NJ631.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=493915 {ECO:0000313|EMBL:ABY71213.1};
RN   [1] {ECO:0000313|EMBL:ABY71213.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NJ631 {ECO:0000313|EMBL:ABY71213.1};
RX   PubMed=19370064; DOI=10.1139/W08-125;
RA   Zhu P., Zheng Y., You Y., Yan X., Shao J.;
RT   "Sequencing and modular analysis of the hybrid non-ribosomal peptide
RT   synthase - polyketide synthase gene cluster from the marine sponge
RT   Hymeniacidon perleve-associated bacterium Pseudoalteromonas sp. strain
RT   NJ631.";
RL   Can. J. Microbiol. 55:219-227(2009).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; EU364530; ABY71213.1; -; Genomic_DNA.
DR   RefSeq; WP_051020069.1; NZ_AKXJ01000006.1.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd17646; A_NRPS_AB3403-like; 1.
DR   CDD; cd17649; A_NRPS_PvdJ-like; 1.
DR   CDD; cd19543; DCL_NRPS; 1.
DR   CDD; cd19534; E_NRPS; 2.
DR   CDD; cd19531; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.40.50.980; -; 4.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   NCBIfam; TIGR01720; NRPS-para261; 2.
DR   PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR   PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          998..1072
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2498..2572
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4013..4088
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   4370 AA;  482525 MW;  262566AD7B872469 CRC64;
     MSQQRRTRRN RAISSLSSED QQRLQARIAE ASETTGQLTM SVAPGEQVPL TAAQQILWYA
     WKMDPADASY NLAGALHFDG QLQSLRVKQA FEVLLAKHSG LRIRFVEAAE QVYQIDGQYQ
     QLDVTELTVH NEQPDDPIRA FVEQPFDLCQ APLLRIAIAT RGTQTSLIVT MHHIITDGTS
     MQQLLDEFVA LYGAQGTADR TPVPGFLEFA KWEQQQERSE LFATQLANWL PHLVETDDTL
     RLPARDHQRH DLNYQVGFET RPVPGALWQR ISALATQYQI TPYLILLTAW QTLLARLSGG
     QHIRVGVPIA NRHRSETQNV VGYFVNTQVM PIQVDDSDSF QQLLAKNTAM SRVAQSNQDL
     PIDKLIEAIK PARQRGVHPV FQVMFNYLRR DKRNFSQLES LSLSGTQMYR FGMPFDLQLD
     VIEDITDGTS LNLVFASELY DADFAVQCLT QLVTLLDTCL SDPDQPINNV SLLQNTQTQA
     LLDIGTGTPA FDYQRPITTL ISEQSARTPE AVALRFAQQS MTYAELEQAS NQLAHCLNTR
     GIGAEDKVAL VFERSLEMVI SILAVVKAGA AYVPLEPSLP LERIAYIASN SGLSLFLGDD
     SLARLDSLSD LAERVTYQSL SLTDYPSQLP EHDIPATQLA YVIYTSGSTG KPKGVVISTA
     RYTTVLPGSS RPIRLAQTTK CCKKPPSGLT CRCGSFSGRM YGAELVIAQP GAHKDSTQLL
     DTINHFGVTT LHFVPSMLQA FIGHEAVHTA TSIRRILCSG EALPSEVQAQ ALSKLPQAKL
     YNLYGPTEAA VDVSHFTCHG DPALPVPIGA PIAGIRLYVL DRALNLCPPG VAGELYIAGT
     GLARGYVNRA DLSAERFVAD PFMNDGSRMY RSGDLVCWNS EGQLDYLGRT DHQVKIRGFR
     IELGEIEAAL YAIDGVREAV IVADRDGATQ RLVGYVSGEA DVELAVDALK AELAAQLPEY
     MVPAVIMVLD TLPLNSNGKI DRKALPKPSH ESSVAYEAPQ GERELALAQV WQKVLGQEQI
     GRLDNFFELG GDSILSLQIV SGLREHDLVV TPKQIFELHT IARLAPALTE LPASQRIAQQ
     VSGEVTLLPI QQQFLATSLS DKNHYNQALL LTLAAPLNGA ALQQVWSALV AHHDALRLCF
     SQNEAGQWQQ RYQPFDAERA VASVWERNVT NAEITSMAEQ AQRSLNIHTG ELARVVHMTL
     DDGTARLLLV IHHLAVDGVS WRVLLDDLAR GYAQAQQQQA CEFASKSHSY QYWAEQIADY
     ASLNSQELAF WTQQQSSALT IPGLNPAGSR RLADSAEVRV TLEQSTTERL LQQAGKPYRT
     VVNELLLSAL SEAVYQWTGQ QETVINLEGH GREPWDAHTD LSRSVGWFTT LYPVHLTRLN
     ALSETIKHTK EHLRSVPNKG IGYGALKYFG ESQAQATLAT QPLGQIEFNY LGQLDNTLNQ
     GDAPWRLASE HSGASFSPDY EPHSELSING QVSDGALQLT ISYGRERIDE ADMQAFAAHL
     HEALTQLVAH CCDTHGCLTP SDVPLSGLDQ QQLDQLPLDT AELSDLYPLS PMQQGMLFHS
     LVEEGEAYVN QTSLEIKRLD VARFKAAWLN AIARHDALRS GFLSLDPRPL QFVRKTVQPI
     WETLDWQHLD SAQQQRQLAE LSVSHRQQGF AMDAESGLQR FTLIQLAPQR HAFVWTIHHI
     LTDGWSCAAL MGEVLRMYDG ETLAEPHAQY GDYIAYLEQQ DVVANLAYWQ TQTGMLEEPC
     YLSGAFKAPQ SGAHAALDVQ LDEAQNTALN AFARQHHLTA NTLMQGAWAL LLSRYLGREA
     VCFGATTSGR PTELAGHESI QGMFINTMPV VVEVAPEVTL AQWLQTLQGT NLAGREHEFT
     PLYEIQKQAK HLTLDQHGLF DTLLVFENYP ITTALPQDEQ ATEFTVRDAR EETNFPLTIS
     FIQEQTLKLH FSYQGSVLAE ADIRALATQF KTLLLTMMDA AQAPLASLLQ LQDASQCSAL
     LDIGTGTPAF DYQRPITTLI SEQSARTPEA VALRFAQQSM TYAELELASN QLAHCLNARG
     IGAEDKVALV FERSLEMVTS ILAVVKAGAA YVPLEPSLPL ERIAYIASNS GLSLFLGDDS
     LARLDGLGDL AERVTYQSLS LADYPSQLPG HDIPANQLAY VIYTSGSTGK PKGVGNQHSA
     IYNRIAWQQS AYPIGADDKV LQKTPFGFDV SVWEYFWPLM YGAELVIAQP GAHKDSAQLL
     DTINHFGVTT LHFVPSMLQA FIGHEAVHTA TSIRRILCSG EALPSEVQAQ ALSKLPLAKL
     YNLYGPTEAA VDVSHFTCHG DPALPVPIGA PIAGIRLYVL DRALNLCPPG VAGELYIAGT
     GLARGYVNRA DLSAERFVAD PFMNDGSRMY RSGDLVCWNS EGLLDYLGRT DHQVKIRGFR
     IELGEIEAAL YAIDGVREAV IVADRDGATQ RLVGYVSGEA DVELAVDALK AELAAQLPEY
     MVPAVIMVLD TLPLNSNGKI DRKALPKPEL NSAVQYVAPQ GKAEQLLAES WQSVLGVAQV
     GRDDNFFALG GDSILSLQII ARLRQGGFSV TAKQLFELQT VARLAPVMTE HTADALPQQN
     VSGQVALLPI QQAFFERNMT HYQHWNQAVM LELATPLTAE QLTQQVAALL TQHDALRLRF
     IRDAAGQWQQ SYRDVSADMA AQSTWYQRAS ISELTDIAEQ AQRSLDLENG PLLRVVHVSL
     DDGTARLLLV IHHLAVDGVS WRILLEDLTT LWQSEQAQLG AKSHSYQFWA QQIQSYASTH
     PAEYAYWQEM ATPQTRFPEL NPAGSRQYQA ADIATLTLDT ATTTALLTQA GQTYRTQVND
     LLLSALSEAL YRWTAQTEHQ INLEGHGREP WNDEVDLSRT VGWFTSLFPV LLTRLPELSD
     TIKYNKEQLR GIPNKGIGYG AFRYYGSASQ RSELAAQTPA EIEFNYLGQL DNVASKEADW
     RPATESTGTA WDPNYEMDTE LSITAQVTEG QLQVLVRYAP QRLPAQQVEI FTAHLQGALE
     EVVAQCAVAE ATFTPSDLPL SGLSQAQIDN LPLALEHVST LYPLSPMQQG MLFQSLYQGG
     ETYVNQSCFM VTGLDVARFK AAWQQVVDRH DALRTGFVDV DGISLQYVAS STELDWQVLD
     WRDRAVSEVE LKAFARQESR RGFDLQGEPG LSRMRIIELS DGRHALVWTM HHILTDGWSR
     AAMLGEVLMA YEGQTLPPVA GQYGDYIAYL AQLDEAQNRA FWQQQLAPLE EPSYLSGTLN
     KPQSGQFGGF DVHLSDAEFA QLVAFCQDHR ITQNTLVQGA WALLLSRYLG RDTVCFGATT
     SGRPNDLAGH DAIQGMFINT VPMVTSVDPA QSLNDWLQAQ QQTALAVREH EFTPLYDIQK
     LAAQSLELSR EGLFDTLLVF ENYPIDEAML QQESRQTRFE VLEDREETNF PLTISFIQEE
     TLRLHFSYQG SELAEADVKA LAAQYKTLIL AMLQTPQARL SEFSLVSETQ QQTLQGLGFG
     ESITPLHSGA VEPIYLPGGE VPQLGATQYQ DVVSTINRLA ELTPDAEAVI CDGRSYSYKV
     LADKSSQLAH YLREQGVKPE QRVGVALARG IDLPLAFLAI LKAGAVYVPM DLSYPQERLA
     YMIKDSQMAH ILTSDNSLDD IAGSATLHPF ADIELSEQWQ QPAVCPAQGA YLIYTSGSTG
     NPKGVLVSRA SIAAHCRGIG RRYEMRPSDR ELIFMSFCFD GAHERWLTVL THGAAVVIRP
     ERQWDLHETY QNLHQQRVSI AVFPPVFLRE LAAHVEQVGN PPPVRVYCFG GDAMPQATFE
     LAQRVLKPDF FINGYGPTET VVTPLTWKAL PGSEFDAVYA PIGELVGQRQ AWLLDSHLNL
     VLPGQVGELY LAEEIGLARG YLNRPDLTAE RFVANPFAND GSRLYRTGDL VRWNEQGLME
     YLGRTDHQVK IRGFRIELGE IETLLRKRPE VRQAVVVADD TPSGKRLVAY VSGHQGELPD
     EAALKAMLTA SLPDYMVPAV IMALSDLPLN SNGKIDRKAL PKAELQSEVS YVAPHNQTEA
     LMAEIWQTVL GVAQVGRRDN FFALGGDSIS GLKVISLWQQ RSEQPLALKQ LWQASDLAAL
     VATMQNADNS VLQPLNPHTD NAETLYCFHE GNGLTAPYRP LAEQLTGQFN CVGVAPAANL
     SGINGLTALA GHYAEALMTA QPQGTFHLMG WSLGGALAVL VARTLKAQGR NVRQVYLVDS
     WNPCSDFAAT QLNWSDWVLE WIGGAAQSVD AALHQAFVAE LTAALQQDLK DADTLATWLV
     AHRTRFAELF NEELLLLPQQ ELGKLLSDGF ELYRLARMTP TEHQLDYTLD GVTERAHTWW
     STDADPVATA AYQTLLGSTV TATHTEDDHQ QIIRAASVQA DLIAKLTQRD
//