ID B0K8T0_THEP3 Unreviewed; 470 AA.
AC B0K8T0;
DT 18-MAR-2008, integrated into UniProtKB/TrEMBL.
DT 18-MAR-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=RNA-directed DNA polymerase (Reverse transcriptase) {ECO:0000313|EMBL:ABY94543.1};
GN OrderedLocusNames=Teth39_0887 {ECO:0000313|EMBL:ABY94543.1},
GN Teth39_1766 {ECO:0000313|EMBL:ABY95403.1};
OS Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium
OS thermohydrosulfuricum).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacter.
OX NCBI_TaxID=340099 {ECO:0000313|EMBL:ABY94543.1, ECO:0000313|Proteomes:UP000002156};
RN [1] {ECO:0000313|Proteomes:UP000002156}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33223 / DSM 2355 / 39E
RC {ECO:0000313|Proteomes:UP000002156};
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J.,
RA Richardson P.;
RT "Complete sequence of Thermoanaerobacter pseudethanolicus 39E.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABY94543.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 33223 {ECO:0000313|EMBL:ABY94543.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J.,
RA Richardson P.;
RT "Complete sequence of Thermoanaerobacter psuedethanolicus 39E.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the bacterial reverse transcriptase family.
CC {ECO:0000256|ARBA:ARBA00034120}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000924; ABY94543.1; -; Genomic_DNA.
DR EMBL; CP000924; ABY95403.1; -; Genomic_DNA.
DR RefSeq; WP_012269208.1; NC_010321.1.
DR AlphaFoldDB; B0K8T0; -.
DR STRING; 340099.Teth39_0887; -.
DR KEGG; tpd:Teth39_0887; -.
DR KEGG; tpd:Teth39_1766; -.
DR eggNOG; COG3344; Bacteria.
DR HOGENOM; CLU_013584_2_1_9; -.
DR Proteomes; UP000002156; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd01651; RT_G2_intron; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR030931; Group_II_RT_mat.
DR InterPro; IPR013597; Mat_intron_G2.
DR InterPro; IPR000123; Reverse_transcriptase_msDNA.
DR InterPro; IPR000477; RT_dom.
DR NCBIfam; TIGR04416; group_II_RT_mat; 1.
DR PANTHER; PTHR34047:SF2; NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR34047; NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF08388; GIIM; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR00866; RNADNAPOLMS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Nucleotidyltransferase {ECO:0000313|EMBL:ABY94543.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002156};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:ABY94543.1};
KW Transferase {ECO:0000313|EMBL:ABY94543.1}.
FT DOMAIN 97..323
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 470 AA; 54973 MW; F8C4DA5405E8A921 CRC64;
MDSKDMQRLQ TTQQRGYPLN REMEFQKTTE VHSISSASKD RRNDVQRYTS KMLEMIVERG
NMRAAYKRVV ANKGSHGVDG MEVDELLPYL KENWATIKQQ LLEGKYKPQP VRRVEISKPD
GGVRLLGIPT ALDRLIQQAI AQILNRVYNH TFSDSSYGFR PGRSAKDAIK AAEAYINEGY
TWVVDMDLEK FFDRVNHDII MSKLEKRIGD KRVLKLIRRY LESGVMINGV KVSTEEGTPQ
GGPLSPLLAN IMLDELDKEL EKRGHKFCRY ADDCNIYVKS RSAGNRVMKS IKKFIESKLK
LKVNEAKSAV DRPWRRKFLG FSFYTKENEV RIRIHEKSIK RFKEKVREIT NRNKGISMEN
RIKRLNQITT GWVNYFGLAD AKSIMKTLDE WIRRRLRACI WKQWKKIKTK HDNLVKLGVE
EQKAWEYANT RKGYWRISNS PILNKTLTNK YFESIGYKSL SQRYLIVHNS
//
