ID B0L653_HUMAN Unreviewed; 375 AA.
AC B0L653;
DT 18-MAR-2008, integrated into UniProtKB/TrEMBL.
DT 18-MAR-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=KIR2DL5 {ECO:0000313|EMBL:ABM92656.1, ECO:0000313|EMBL:CDX48189.1};
DE SubName: Full=Killer cell immunoglobulin-like receptor {ECO:0000313|EMBL:QKY12217.1, ECO:0000313|Ensembl:ENSP00000484782.1};
DE SubName: Full=Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 5 {ECO:0000313|EMBL:AJI81014.1};
DE Flags: Fragment;
GN Name=KIR2DL5B {ECO:0000313|EMBL:ABM92656.1,
GN ECO:0000313|Ensembl:ENSP00000484782.1};
GN Synonyms=KIR2DL5 {ECO:0000313|EMBL:AJI81014.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABM92656.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000484782.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|EMBL:ABM92656.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18461314; DOI=10.1007/s00251-008-0273-7;
RA Mulrooney T.J., Hou L., Steiner N.K., Chen M., Belle I., Ng J.,
RA Hurley C.K.;
RT "Promoter variants of KIR2DL5 add to diversity and may impact gene
RT expression.";
RL Immunogenetics 60:287-294(2008).
RN [3] {ECO:0000313|EMBL:CDX48189.1}
RP NUCLEOTIDE SEQUENCE.
RA Nemat-Gorgani N., Norman P.J., Parham P.;
RT "KIR Diversity in Africans.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AJI81014.1}
RP NUCLEOTIDE SEQUENCE.
RA Roe D., Vierra-Green C., Pyo C.-W., Eng K., Hall R., Spellman S.,
RA Ranade S., Geraghty D.E., Maiers M.;
RT "Full Haplotype Sequences of the Killer Immunoglobulin-like Receptor (KIR)
RT Region in Several Diverse Diploid Individuals using Single Molecule, Real-
RT Time Sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:SHO29775.1}
RP NUCLEOTIDE SEQUENCE.
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:SHO29775.1}
RP NUCLEOTIDE SEQUENCE.
RA Neda Nemat-Gorgani N.G., Paul J.Norman.P.J.N., Peter Parham P.P.;
RT "African allele diversity.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QKY12217.1}
RP NUCLEOTIDE SEQUENCE.
RA Roe D., Vierra-Green C., Spellman S., Maiers M., Kuang R.;
RT "A Detailed View of KIR Haplotype Structures and Gene Families as Provided
RT by a New Motif-based Multiple Sequence Alignment.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Ensembl:ENSP00000484782.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; GU182345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EF379097; ABM92656.1; -; Genomic_DNA.
DR EMBL; KP420441; AJI81014.1; -; Genomic_DNA.
DR EMBL; LM656217; CDX48189.1; -; Genomic_DNA.
DR EMBL; MN167506; QKY12217.1; -; Genomic_DNA.
DR EMBL; MN167510; QKY12241.1; -; Genomic_DNA.
DR EMBL; MN167519; QKY12315.1; -; Genomic_DNA.
DR EMBL; MN167525; QKY12367.1; -; Genomic_DNA.
DR EMBL; MN167526; QKY12378.1; -; Genomic_DNA.
DR EMBL; LT630465; SHO29775.1; -; Genomic_DNA.
DR AlphaFoldDB; B0L653; -.
DR SMR; B0L653; -.
DR MassIVE; B0L653; -.
DR Ensembl; ENST00000614018.4; ENSP00000484782.1; ENSG00000275946.5.
DR Ensembl; ENST00000639186.1; ENSP00000491226.1; ENSG00000283742.3.
DR Ensembl; ENST00000644442.1; ENSP00000493588.1; ENSG00000283742.3.
DR UCSC; uc061feu.1; human.
DR HGNC; HGNC:16346; KIR2DL5B.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF169; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL5A-RELATED; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:AJI81014.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..375
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015086968"
FT TRANSMEM 239..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..116
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 129..216
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT REGION 213..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 375
FT /evidence="ECO:0000313|EMBL:ABM92656.1"
SQ SEQUENCE 375 AA; 40664 MW; A7B71285352F0834 CRC64;
MSLMVVSMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL
YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL
FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVNGTFQADF
PLGPATHGGT YTCFGSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH
ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ
LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL
SQNRVASSHV PAAGI
//
