ID B0MM35_9FIRM Unreviewed; 716 AA.
AC B0MM35;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Diguanylate cyclase (GGDEF) domain protein {ECO:0000313|EMBL:EDS01213.1};
GN ORFNames=EUBSIR_00884 {ECO:0000313|EMBL:EDS01213.1};
OS [Eubacterium] siraeum DSM 15702.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Oscillospiraceae incertae sedis.
OX NCBI_TaxID=428128 {ECO:0000313|EMBL:EDS01213.1, ECO:0000313|Proteomes:UP000005326};
RN [1] {ECO:0000313|EMBL:EDS01213.1, ECO:0000313|Proteomes:UP000005326}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15702 {ECO:0000313|EMBL:EDS01213.1,
RC ECO:0000313|Proteomes:UP000005326};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDS01213.1, ECO:0000313|Proteomes:UP000005326}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15702 {ECO:0000313|EMBL:EDS01213.1,
RC ECO:0000313|Proteomes:UP000005326};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Eubacterium siraeum (DSM 15702).";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDS01213.1}.
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DR EMBL; ABCA03000040; EDS01213.1; -; Genomic_DNA.
DR AlphaFoldDB; B0MM35; -.
DR Proteomes; UP000005326; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR46663; DIGUANYLATE CYCLASE DGCT-RELATED; 1.
DR PANTHER; PTHR46663:SF2; GGDEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..716
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002750503"
FT TRANSMEM 307..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 331..383
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 457..509
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 541..674
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT REGION 680..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 79922 MW; EC0CE9F1B469055A CRC64;
MKIKSLLITV LACFVIIPSV AFACIADVEM NKLAMKNYKQ TAQSMAENQT YNISEYFRII
SASAKQIADN PDILSFDKEK NPTTTDALSI YSNIASADNP NVRIDRIMIV NKSDFRPVVG
TNEDFNDLTR DDVLYGTLKK ICARKDGEVT FYTPDVYTNF NEGDKEKNDP LFPGKTANGL
RLVVKYSVGD YYIVTFFNNT ALKSFATSSQ FANNSKLVLI DPNGSIMHDS YIGNTSDKKN
SAYLKFTEAA QTGSAVEVDN FKGTDSGVIP TISFTSKMPT INEGEEGNWT LAIIAETDKA
YTLSGEAMGA IVGMIVLVAI IFTAGAIVLV FIITKPIKVI EETLVKVHRG DHEARINVIA
NNEYGQIART FNDLIDDIVV SEGRYRTIIE MSDNIIFEWN FKSNDVFFSN NFNKKFSYRA
PSDHFGDSFL LKVKVHPEDN DRYHKDLEKL SKGEEFEGNE YRWKNIYGDY IWILMRTATI
RDRDGNIAKI VGVIVDIDRA KKSEKLLTER ASYDSLTGLY NRESIERTID NEIELINVRK
SEVAILFIDV DDFKIYNDKY SHATGDQVLK FVANTINFVI KGFGTAGRYG GDEFVACVRN
IETNEPTRVA RDILSGLKEG FTSDNGDKLS VNASIGISII KDSSMHVDEI IGMADDAMYK
IKKNGKSNFG ILNKEMVERP VPDKVDEEDV IGGSNSNNIG DSVAPDTAND TAEQQQ
//
