ID   B0SJF3_LEPBP            Unreviewed;       694 AA.
AC   B0SJF3;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=Bifunctional diguanylate cyclase/phosphodiesterase {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=LEPBI_I0307 {ECO:0000313|EMBL:ABZ96451.1};
OS   Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris).
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=456481 {ECO:0000313|EMBL:ABZ96451.1, ECO:0000313|Proteomes:UP000001847};
RN   [1] {ECO:0000313|EMBL:ABZ96451.1, ECO:0000313|Proteomes:UP000001847}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Patoc 1 / ATCC 23582 / Paris
RC   {ECO:0000313|Proteomes:UP000001847};
RX   PubMed=18270594; DOI=10.1371/journal.pone.0001607;
RA   Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N.,
RA   Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A.,
RA   Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L.,
RA   Rood J.I., Lajus A., Davies J.K., Medigue C., Adler B.;
RT   "Genome sequence of the saprophyte Leptospira biflexa provides insights
RT   into the evolution of Leptospira and the pathogenesis of leptospirosis.";
RL   PLoS ONE 3:E1607-E1607(2008).
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DR   EMBL; CP000786; ABZ96451.1; -; Genomic_DNA.
DR   RefSeq; WP_012387339.1; NC_010602.1.
DR   AlphaFoldDB; B0SJF3; -.
DR   STRING; 456481.LEPBI_I0307; -.
DR   KEGG; lbi:LEPBI_I0307; -.
DR   HOGENOM; CLU_000445_70_20_12; -.
DR   OrthoDB; 310793at2; -.
DR   BioCyc; LBIF456481:LEPBI_RS01500-MONOMER; -.
DR   Proteomes; UP000001847; Chromosome I.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001847}.
FT   DOMAIN          12..82
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          134..210
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          294..427
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          436..690
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   694 AA;  79037 MW;  DC19B21593A891DC CRC64;
     MRNEPLGKNI LSGLTVKSLL SEYPNSFQVL DWEGNFVSVT DRFARFLEFE PKEIVGKSIL
     NFTQEDDKEN TQNTFEGLGE NPNIVNFENR LVTKSKEEVW IIWLLIPLTD SKIILGFDRD
     VTIQKDISFE FLLQQQKYKS IFDNLPMGIA ITDEKGKIVE TNKTARTYFD IQDGELLNRT
     LNIRKYTLIQ PNGTKIYPRK SSLMRALRHK EVIRNLEIGM IKENKITWFD ILATPIPIEN
     FGLAVAFLDI TQRRHAEEKI AYMAFFDQLT NLPNRNSLID KLFPIFEEAR RHGNLVGILA
     IDLDNFKIIN DSRGHDFGDK IIKLVAYRIR ESIRVYDLIS RQGGDEFTVV LPDLSNERDA
     AVISESILDA MTHPFVIDGE RIFVNISIGI ALYPTDGKDS NTLLKNADSA LNLAKSQGKN
     CYVFFTEELQ TVVAERLEIE NRMRIAIIEN QFTLMYQPKI DLYTRKPVGV EALIRWRHPE
     RGLISPNVFI PISEETGMIL AIGEWVIKSA IKTMREWKDH GVKDISMAVN ISTKQFKHER
     LISTIAENLK LYKVDPHDLE VELTESSVME NADAAVRTMQ EIRKLGAKIA IDDFGTGYSS
     LGYLKKLPIS SLKIDRSFVS EITTDKDSKT IIHAVSNLAH NLGLSVVAEG AETEEQVRLL
     AESGVDQIQG FYFAKPMTSE DCLHFLKTEL GISD
//