ID B0SKM2_LEPBP Unreviewed; 317 AA.
AC B0SKM2;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Octoprenyl-diphosphate synthase (Octaprenyl pyrophosphate synthetase OPP synthetase) {ECO:0000313|EMBL:ABZ96779.1};
DE EC=2.5.1.- {ECO:0000313|EMBL:ABZ96779.1};
GN Name=ispA2 {ECO:0000313|EMBL:ABZ96779.1};
GN OrderedLocusNames=LEPBI_I0646 {ECO:0000313|EMBL:ABZ96779.1};
OS Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=456481 {ECO:0000313|EMBL:ABZ96779.1, ECO:0000313|Proteomes:UP000001847};
RN [1] {ECO:0000313|EMBL:ABZ96779.1, ECO:0000313|Proteomes:UP000001847}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Patoc 1 / ATCC 23582 / Paris
RC {ECO:0000313|Proteomes:UP000001847};
RX PubMed=18270594; DOI=10.1371/journal.pone.0001607;
RA Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N.,
RA Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A.,
RA Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L.,
RA Rood J.I., Lajus A., Davies J.K., Medigue C., Adler B.;
RT "Genome sequence of the saprophyte Leptospira biflexa provides insights
RT into the evolution of Leptospira and the pathogenesis of leptospirosis.";
RL PLoS ONE 3:E1607-E1607(2008).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|ARBA:ARBA00006706, ECO:0000256|RuleBase:RU004466}.
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DR EMBL; CP000786; ABZ96779.1; -; Genomic_DNA.
DR RefSeq; WP_012387666.1; NC_010602.1.
DR AlphaFoldDB; B0SKM2; -.
DR STRING; 456481.LEPBI_I0646; -.
DR KEGG; lbi:LEPBI_I0646; -.
DR HOGENOM; CLU_014015_2_0_12; -.
DR OrthoDB; 9805316at2; -.
DR BioCyc; LBIF456481:LEPBI_RS03180-MONOMER; -.
DR Proteomes; UP000001847; Chromosome I.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR12001:SF87; OCTAPRENYL DIPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000001847};
KW Transferase {ECO:0000256|RuleBase:RU004466, ECO:0000313|EMBL:ABZ96779.1}.
SQ SEQUENCE 317 AA; 36340 MW; 93F5B4390D4B1642 CRC64;
MKSKIKIQSV LSKFDKNLDS IIHEDIPILK KIKKQVITSG GKRIRPFSHY LFCQFMNVKD
VSWLDVGSVA ELIHAASLLH DDVVDNAPIR RGKPTIGASF GNKTAILAGD YLLACGISRL
NSLGNPDLME IFSQVLRDLS VSELLQMEWE KNPNITLKIY DQIIYGKTAS LFGVCTEAAA
ILANQSKEKR KEFRQFGVRL GKLFQKKDDC LDYFEDSKAS GKEFLKDFKN GLFTYPVLVL
RSKLNLLEKR KLNRLFQKEI RDVKDESIIL DLMNSKKIPA ILHKELESEK NDLLRFLNQF
PKSEERELFI EQLSRLT
//
