ID B0W4I9_CULQU Unreviewed; 507 AA.
AC B0W4I9;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Cytochrome P450 4d1 {ECO:0000313|EMBL:EDS33572.1};
GN Name=6033131 {ECO:0000313|EnsemblMetazoa:CPIJ001758-PA};
GN ORFNames=CpipJ_CPIJ001758 {ECO:0000313|EMBL:EDS33572.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS33572.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS33572.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ001758-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ001758-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; DS231837; EDS33572.1; -; Genomic_DNA.
DR RefSeq; XP_001843623.1; XM_001843571.1.
DR AlphaFoldDB; B0W4I9; -.
DR EnsemblMetazoa; CPIJ001758-RA; CPIJ001758-PA; CPIJ001758.
DR KEGG; cqu:CpipJ_CPIJ001758; -.
DR VEuPathDB; VectorBase:CPIJ001758; -.
DR VEuPathDB; VectorBase:CQUJHB004365; -.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_001570_5_1_1; -.
DR InParanoid; B0W4I9; -.
DR OMA; ISFGEKW; -.
DR OrthoDB; 1611592at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20628; CYP4; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF187; CYTOCHROME P450 4AE1-RELATED; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
SQ SEQUENCE 507 AA; 58785 MW; D278C783E339ACB5 CRC64;
MWLVLSLIIA TFGYLLFNYH KTRQKLLAIQ SHFNGPPTHY FLGNFPIFIG KSIPDIFNII
TKMHKVYGED IAIIAAFNEL VIDLSSSRNV EKVLLAKSIK KSFVYNFLEP WLGTGLLTVP
TGEKWFQRRK IITPTFHFKM LDNFLEVFNR EADVLVEKLK VRAGKGEFDI YDYVTLYALD
SICETSMGVQ IHAQDDPGNE YAIAVKQMST FILRRIFNPL RSFPRLFFLF PFAKEQKNVI
RKLHNFTNSV IDSRRKVLER EQASSTVAFD LQEENMYSKR KITFLDLLLS VTVEGKPLSR
EDIREEVDTF MFEGHDTTTS GISFTIWHLA KHQDVQQKLC DEIDQILGTE KKTAELTNVK
IQEFEYLDMV VKESLRLIPP VPIIGRQLIE DLEMNGTTIP AGTQINIKIY NIHRNPKIWP
DPERFDPDRF SKTNEDKRGP YDYIPFSAGS RNCIGQRYAM MELKVTLIKL LASYRILPGE
SMEKMRFKTD LVIRPNETIP IKLVERG
//
