ID B0W5U1_CULQU Unreviewed; 1109 AA.
AC B0W5U1;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Gamma-aminobutyric acid type B receptor {ECO:0000313|EMBL:EDS35744.1};
GN ORFNames=CpipJ_CPIJ002466 {ECO:0000313|EMBL:EDS35744.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS35744.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS35744.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS231844; EDS35744.1; -; Genomic_DNA.
DR RefSeq; XP_001844075.1; XM_001844023.1.
DR AlphaFoldDB; B0W5U1; -.
DR STRING; 7176.B0W5U1; -.
DR KEGG; cqu:CpipJ_CPIJ002466; -.
DR VEuPathDB; VectorBase:CPIJ002466; -.
DR VEuPathDB; VectorBase:CQUJHB007700; -.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_005789_1_0_1; -.
DR InParanoid; B0W5U1; -.
DR OMA; TISPMAF; -.
DR OrthoDB; 2970339at2759; -.
DR PhylomeDB; B0W5U1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF46; METABOTROPIC GABA-B RECEPTOR SUBTYPE 3, ISOFORM A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EDS35744.1}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1109
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002758926"
FT TRANSMEM 506..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 692..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 723..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 579..784
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 70..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1109 AA; 123052 MW; E90C7EE19E03E068 CRC64;
MVLRFTVILL CGFVAGMSSS PSSNSGENFD KFTRGPEFAA RSRILRNVVD KSRMVNGSAA
TTTRVLNRNS INTVFEERTR PNSDSGGGGG TGSRQRRQRE VSILGLFELS TRHGMRAEGQ
SELAAAQLAV QHINRRGLLL GYTLKLLTND TKCDPGVGID RFFHALYTHQ DKRIIMVLGS
ACSEVTESVA KVVPYWNIVQ VSFGSTSPAL SDRREFPLFY RTVAPDSSHN PARIAFIKHF
GWDTVATFAE NEEGHSLAVN DLVTELERAN ITCAATISFA ETDFKEQLKL LRAYFLGMFG
ADYAWILQDT HISSWWLAPT SACPSAILLK ALDNVLLVSS YNSIVGMGTA LSGLTDEMFH
RKLTEMNVTG AVSRFAPQTY DAVWAMALAL RGAERTWTQV AHQNRTRLSH YDYTRFDMAK
ELLRQFDSLR FNGISGPVSF DGADRVGTTS FHQIQSGVLR QIAFYYPKNA SLDFGCPKCG
AIRWESGQVP IAKRILRLRV DTISPMAFYT VVILSIVGIG ISVLFLAMNL HFRKLKAMKL
SSPKLSTITV CGCILVYMAT ILLGLDDSTL PSWPSVTFST ICMARIYFLS AGFSLAFGSM
FAKTFRVYRL FTHSAGGLCK DKILRDTQLI SVIGALLLLD ACVVSFWMAA DPMERHLHNL
TLEISASDRG VVYLPQVELC RSRHYESWLG TLYAYKGLLL IVGVYMAWQT RNVKIPALND
SQYIGVSVYS VVITSASVVV LANLLYEKVT LAFAITAGFI LISTTATLCL LFLPKLKDIF
DKGEVYDPVI HSMGLKMECN TRRFVVDDRR ELQFRVEVQN RVYRKEIEML DAEIVRLERL
LTDRPSQSPS RSSDPNVKPL VDSLETFNGT PLMNPSAPTG LPMLLLSVLP PIIPRASWPT
VDPMLSPMKR NVTFSSQPRI AFGRDRNCLS ELRLSNTEEG GGVLSRIKNL FGSRVHKTSS
ISALGGPNMA VRPSTLTIFA EVDAEDDVSG AGEVFTIKQP SNENLRLTGS EPRVNFVLPT
IEHRRPSIVH QHSQPTLRER IRGSPRFPHR VCPTASSMTE LMMTGGDQQT LPRMSFLTVK
SCEVLQGSNQ PTTIKWQSMD SFANGVGKC
//
