ID B0W8U9_CULQU Unreviewed; 734 AA.
AC B0W8U9;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 93.
DE SubName: Full=Annulin {ECO:0000313|EMBL:EDS39328.1, ECO:0000313|EnsemblMetazoa:CPIJ003524-PA};
GN Name=6034896 {ECO:0000313|EnsemblMetazoa:CPIJ003524-PA};
GN ORFNames=CpipJ_CPIJ003524 {ECO:0000313|EMBL:EDS39328.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS39328.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS39328.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ003524-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ003524-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; DS231860; EDS39328.1; -; Genomic_DNA.
DR RefSeq; XP_001845164.1; XM_001845112.1.
DR AlphaFoldDB; B0W8U9; -.
DR STRING; 7176.B0W8U9; -.
DR EnsemblMetazoa; CPIJ003524-RA; CPIJ003524-PA; CPIJ003524.
DR KEGG; cqu:CpipJ_CPIJ003524; -.
DR VEuPathDB; VectorBase:CPIJ003524; -.
DR VEuPathDB; VectorBase:CQUJHB010706; -.
DR eggNOG; ENOG502QQ46; Eukaryota.
DR HOGENOM; CLU_013435_0_1_1; -.
DR InParanoid; B0W8U9; -.
DR OMA; NHRTSRY; -.
DR OrthoDB; 5344745at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF69; RE08173P; 1.
DR Pfam; PF00927; Transglut_C; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 285..382
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 293
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 352
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 379
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 419
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 421
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 469
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 474
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 734 AA; 83041 MW; 9BB8A3C1574F31B4 CRC64;
MEHSPSSDVL TIKSVDLCIE ENGKSHHTKR YELMTRDGQY GAPAALVIRR GQAFRLRLTC
DRPFDRSRDA MSLIFTVDQD ERPTHGHGSL VGVALQQYRH MIEDPLEWAA AIDFVSGDVL
EILVKPAANA LVTKWKLDFD TKLLSEGFGK SYSLPQPFYL LFNPWCKDDQ VYLEDKALRD
ECVMNDTTLI WRGSYNRLRP SVWKFGQFDK HVLDCALLLI AKVGKVSATH RGDPILVCRA
ISAAVNSPDD DGALLGNWSG DFSGGIAPTK WVGSVEILQQ FYKKQKPVKF AQCWVFAGVV
STIARAIGIP SRVITNYSSA HDTQASLTVD YFVDKNGKIM EEMNSDSIWN YHVWNEVWMQ
RPDLGIGSDG DYGGWQAIDA TPQEMSDGMF RCGPASVLAV KLGEIAKPYD NNFLFAEVNA
DKVFWRYTGP AHPLKLIRKD VFGIGHFIST KAVGKWERED VTSSYKFAEK SQEERDTMLK
ALKQANSAFS RYYLNEDFNE VYFNFELRDD IKIGEAFSVI LQIKNRSSET PHTINGYLNV
ETVLYTGKQR EFVKKHPFTV NLDPASEEFI RMEVSFDEYY KKLRDQAAFN ISCFATVENT
DYEFFAQDDF RVRKPDIKIK LADTPVSQSP VEVTIALLNP LPIPLRKGIF HVEGSGIEKP
LIFKHPEVAV DETINNIFVL TPPFAGRGTI AAKFTSRELD DVDGFVAFEA KPRSEDVLME
TSDNEVIERT DIID
//
